腸道是我們身體其中一道消化器官,其內壁表面含有名為絨毛(villi)的結構,輔助營養的吸收;525Please respect copyright.PENANAYW5IFwwS5v
而絨毛與絨毛之間,則有名為crypt的凹陷結構。525Please respect copyright.PENANAfPTxLQC3cB525Please respect copyright.PENANAYebdeD1IJA
525Please respect copyright.PENANAvAvnIvdVrv
525Please respect copyright.PENANAc1mFHuU73Q
(圖2)凹陷的crypt結構大多由幹細胞構成,它們會自我複製及演化,且不斷向上發展到達villi結構,形成可負責幫忙吸取營養的細胞。525Please respect copyright.PENANAI3vKBRoNXc525Please respect copyright.PENANAvArJoq8vRW
525Please respect copyright.PENANA6SXbwBONaR
525Please respect copyright.PENANAkxcwNHVGLG
(圖3)若位於crypt的幹細胞出現相應的基因突變(KrasG12D /PIK3CAH1047R ),它們會釋放出界別為BMP activator及WNT inactivator的物質,而當鄰近的正常細胞吸取這些物質後,出現基因突變的機率亦會提升。525Please respect copyright.PENANAn68CavDnDz525Please respect copyright.PENANANvYxqsH0Nw
525Please respect copyright.PENANARiR6Detjr2
換句話說,只要一顆位於crypt的幹細胞出現突變的話,便會出現火燒連環船一樣的效果,一傳十十傳百的透導各鄰近的細胞出現異變,成為癌細胞的一份子。525Please respect copyright.PENANAt8TpfZGslh
525Please respect copyright.PENANAf6p3InQRtH
525Please respect copyright.PENANAfkEhI4Xkpo
525Please respect copyright.PENANA4ETxwsyvu3
如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。525Please respect copyright.PENANAtvIOonpqXJ
525Please respect copyright.PENANAWeqdoEo925
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc525Please respect copyright.PENANAUs7jj4gzN0
525Please respect copyright.PENANAhElU0SVDLu
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。525Please respect copyright.PENANARMx4CQvrLU
525Please respect copyright.PENANA1QOaA9QaOy
Link:525Please respect copyright.PENANAX618GaGfa3
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio525Please respect copyright.PENANAvmoTShLTah
525Please respect copyright.PENANALZXL5vek5Z
525Please respect copyright.PENANAc7FuEuGSGa
除非Facebook及IG重開侵侵的account,否則我的IG將不會再作更新,只會寄居本土LIHKG及Penana。525Please respect copyright.PENANAlUy5t2RCNs
525Please respect copyright.PENANA1EAkaHgVP3
Ref1:https://www.nature.com/articles/s41586-021-03605-0
525Please respect copyright.PENANAGlPp5hRu0w