往不同動物例如老鼠及線蟲注射治療糖尿病的藥物(Metformin)後，壽命均會有顯著的增長。762Please respect copyright.ＰＥＮＡＮＡH8JCdChVW5
762Please respect copyright.ＰＥＮＡＮＡsoSPJOewVX
762Please respect copyright.ＰＥＮＡＮＡdhrbm7frjS
有研究利用現成資料庫作對比，發現服用Metformin的糖尿病人歲數比沒有服用Metformin的健康人士為長(Ref1)，亦有臨床研究嘗試為14名70歲的健康老人家注射為期6星期的Metformin，藉觀察體內的轉變以作抗衰老藥的研究基礎(Ref2)。762Please respect copyright.ＰＥＮＡＮＡ9NVxTVnzFN
762Please respect copyright.ＰＥＮＡＮＡ4rijncVjEZ
（圖2）從圖中可見，往年輕線蟲注射Metformin的話，牠們的生存日子便會增長。762Please respect copyright.ＰＥＮＡＮＡDvP0kj2kDS
762Please respect copyright.ＰＥＮＡＮＡuLGCxUJ2gA
762Please respect copyright.ＰＥＮＡＮＡyJziFiqD0Z
（圖3）但是，與年輕線蟲相反，往年老的線蟲注射Metformin的話，牠們的生存日子不但沒有增加，反而會減少。762Please respect copyright.ＰＥＮＡＮＡEYdvwA9C4Z
762Please respect copyright.ＰＥＮＡＮＡGKbjDnIfh5
762Please respect copyright.ＰＥＮＡＮＡbrmykOWm6D
762Please respect copyright.ＰＥＮＡＮＡ68rZZ6MLjZ
（圖4）經過一系列的實驗，科學家認為Metformin能夠驅使年輕線蟲延壽的其中一個原因，是與粒線體的整體功用有關(Ref3)。762Please respect copyright.ＰＥＮＡＮＡg41z2PNFo2
762Please respect copyright.ＰＥＮＡＮＡlH2vEwz1aN
762Please respect copyright.ＰＥＮＡＮＡ430q0USkWG
其中，Metformin為年輕線蟲的新陳代謝作出轉變，包括增加碳水化合物的分解，減低脂肪的含量等，但年老的線蟲卻沒能夠觸發同樣的效果，反而更會因新陳代謝機制的不良負荷而增加死亡率。762Please respect copyright.ＰＥＮＡＮＡp3coOel2AN
762Please respect copyright.ＰＥＮＡＮＡmfQOxLexhT
文中的科學家亦就此作出質疑，既然Metformin只能使年輕線蟲而非年老線蟲延壽，那又究竟是否值得「魯莽」地對健康老人家進行Metformin的延壽研究。762Please respect copyright.ＰＥＮＡＮＡJuBpm9MrdM
762Please respect copyright.ＰＥＮＡＮＡLDP5YoUbXE
762Please respect copyright.ＰＥＮＡＮＡlWVULn4nsO
如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。762Please respect copyright.ＰＥＮＡＮＡzQrYrBh0YF
762Please respect copyright.ＰＥＮＡＮＡ3EUksb0O9G
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc762Please respect copyright.ＰＥＮＡＮＡcSrNYjIXyT
762Please respect copyright.ＰＥＮＡＮＡ0f251gNgx8
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。762Please respect copyright.ＰＥＮＡＮＡVLwuyao4jE
762Please respect copyright.ＰＥＮＡＮＡyl2WuHyW2F
Link:762Please respect copyright.ＰＥＮＡＮＡ59mfvPWg6t
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio762Please respect copyright.ＰＥＮＡＮＡc2Ka0StJoY
762Please respect copyright.ＰＥＮＡＮＡMykvtKByAM
有興趣接收科學資訊的話，歡迎follow IG: potatopigtongue。762Please respect copyright.ＰＥＮＡＮＡGmuHCmOOkH
762Please respect copyright.ＰＥＮＡＮＡd7e3ZSPjyA
https://www.instagram.com/potatopigtongue/762Please respect copyright.ＰＥＮＡＮＡ25FfDxXgb3
762Please respect copyright.ＰＥＮＡＮＡ98dTwhcz8M
762Please respect copyright.ＰＥＮＡＮＡXbigMdD39P
762Please respect copyright.ＰＥＮＡＮＡVO7jTUKOxs
762Please respect copyright.ＰＥＮＡＮＡkxpzTbEKDT
Ref1:https://pubmed.ncbi.nlm.nih.gov/25041462/762Please respect copyright.ＰＥＮＡＮＡyyv4m04iIu
Ref2:https://pubmed.ncbi.nlm.nih.gov/29383869/762Please respect copyright.ＰＥＮＡＮＡSp93mUU487
Ref3:https://www.nature.com/articles/s42255-020-00307-1762Please respect copyright.ＰＥＮＡＮＡRPTJUOM3o0
Penana
search
Loginarrow_drop_down
Registerarrow_drop_down
