肌肉大概佔據身體重量的40%。531Please respect copyright.PENANAe0ZceQ7e5Y531Please respect copyright.PENANA3WJPIjgJd7
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踏入50歲後,平均每10年就會有15-30%的肌肉流失。531Please respect copyright.PENANANLqPCLfFiv
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(圖2)研究(Ref1)顯示老人家的肌肉裡頭,一隻名為15-PGDH的蛋白酶數量普遍地比年輕人為高。531Please respect copyright.PENANAdsQuhlDcWZ531Please respect copyright.PENANATUnkzlduAD
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而15-PGDH其中一道作用就是負責將激素PGE2及PGD2分解成為其他物質。531Please respect copyright.PENANA17hWD7sVFt
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(圖3)而人類老化所出現的現象,老鼠亦能同樣發現得到。531Please respect copyright.PENANAI86gvOswyr
除肌肉外,年長老鼠的心、肝、脾、大腸及皮膚亦出現15-PGDH蛋白酶上升的現象。531Please respect copyright.PENANAujYWCr4g7P531Please respect copyright.PENANA5If8gQJS9e
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當利用藥物或基因工程手段降低年老老鼠的15-PGDH數量的話,肌肉重量亦會有所提升。531Please respect copyright.PENANAnvR3f7F4dK
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相反,若強行在年輕老鼠肌肉裡頭強行表達15-PGDH的話,肌肉重量亦會有所下降。531Please respect copyright.PENANA6O41r3Kbt0
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這道研究展示出,只需對一隻蛋白酶作出針對性的抑制,便能夠達到控制肌肉重量及結構的奇效。531Please respect copyright.PENANAwirmyGYwyO
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現時已有藥物可抑制15-PGDH,但對於人類肌肉影響的臨床研究則欠奉。531Please respect copyright.PENANAUAk5kQ2tAp
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只不過的是,現今均普遍認為增加體內細胞NAD數量的話,便可舒緩甚至是扭轉細胞的老化現象。然而,15-PGDH卻需要NAD才能正常運作,這一方面所出現的矛盾則未能解釋得到。531Please respect copyright.PENANAd6DdQ5Eklk
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如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。531Please respect copyright.PENANAoKI8lZXMQm
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Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc531Please respect copyright.PENANAGIfxb6RIPr
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同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。531Please respect copyright.PENANAU4NYKfBAF6
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https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio531Please respect copyright.PENANA0xic5bBj9A
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基於WhatsApp/Facebook等問題,IG將不會再作更新,只會寄居本土LIHKG及Penana。531Please respect copyright.PENANAquMaV1kJ7T
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Ref1:https://science.sciencemag.org/content/371/6528/eabc8059531Please respect copyright.PENANAKZSrstNtnB