肌肉大概佔據身體重量的40%。506Please respect copyright.PENANACuoM9QT3cV506Please respect copyright.PENANAWKVaSFCEry
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踏入50歲後,平均每10年就會有15-30%的肌肉流失。506Please respect copyright.PENANAXjLqQu57cP
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(圖2)研究(Ref1)顯示老人家的肌肉裡頭,一隻名為15-PGDH的蛋白酶數量普遍地比年輕人為高。506Please respect copyright.PENANAH5SNsqPFVx506Please respect copyright.PENANAr9KMqu8Vj4
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而15-PGDH其中一道作用就是負責將激素PGE2及PGD2分解成為其他物質。506Please respect copyright.PENANA8euuJ9n5Jr
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(圖3)而人類老化所出現的現象,老鼠亦能同樣發現得到。506Please respect copyright.PENANAksu8FfFP5l
除肌肉外,年長老鼠的心、肝、脾、大腸及皮膚亦出現15-PGDH蛋白酶上升的現象。506Please respect copyright.PENANAGpcSrAxOmb506Please respect copyright.PENANAdmR3DUuprK
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當利用藥物或基因工程手段降低年老老鼠的15-PGDH數量的話,肌肉重量亦會有所提升。506Please respect copyright.PENANAwiQ7SB95gk
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相反,若強行在年輕老鼠肌肉裡頭強行表達15-PGDH的話,肌肉重量亦會有所下降。506Please respect copyright.PENANARzbendVHIp
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這道研究展示出,只需對一隻蛋白酶作出針對性的抑制,便能夠達到控制肌肉重量及結構的奇效。506Please respect copyright.PENANAbpxPuSYW1k
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現時已有藥物可抑制15-PGDH,但對於人類肌肉影響的臨床研究則欠奉。506Please respect copyright.PENANAsnRMw4t8aB
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只不過的是,現今均普遍認為增加體內細胞NAD數量的話,便可舒緩甚至是扭轉細胞的老化現象。然而,15-PGDH卻需要NAD才能正常運作,這一方面所出現的矛盾則未能解釋得到。506Please respect copyright.PENANAPIu3mEXzu8
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https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio506Please respect copyright.PENANAkVHjrm7beC
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基於WhatsApp/Facebook等問題,IG將不會再作更新,只會寄居本土LIHKG及Penana。506Please respect copyright.PENANA5pXa7LlmcD
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Ref1:https://science.sciencemag.org/content/371/6528/eabc8059506Please respect copyright.PENANAZJU8R1iJkh