不少的癌症病人均會出現體重及BMI急速下降的情況,肌肉會出現萎縮,脂肪組織亦有機會有所消耗,這現象稱之為Cancer-associated cachexia(CAC)。572Please respect copyright.PENANAJSrTIr3QCr572Please respect copyright.PENANAR4Zfcp2uBJ
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與厭食症不同的是,體重的流失並沒能依靠增加進食來進行完全填補。572Please respect copyright.PENANAhj5HBkpmoH
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(圖2)CAC的形成,是腫瘤與身體多種器官互動後所得出的結果,箇中涉及新陳代謝及荷爾蒙的轉變。572Please respect copyright.PENANAdxqo2oOOxX572Please respect copyright.PENANA9AcKEpQyKx
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(圖3)從圖中所見,老鼠出現腫瘤約21日後,腿部肌肉出現萎縮,與人類的CAC現象吻合。572Please respect copyright.PENANANjzgqW39Sv572Please respect copyright.PENANAfkXQUL7ciz
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PTHrP是一種某類型的腫瘤釋放到血管的蛋白質,而往老鼠注射PTHrP蛋白質抗體的話,肌肉的萎縮程度亦有所緩和。572Please respect copyright.PENANAZtiayWuu27
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只可是,往健康老鼠注射PTHrP蛋白質的話,肌肉並不會貿然萎縮,而往出現腫瘤的老鼠注射PTHrP蛋白質的話,肌肉萎縮的程度反會更加劇烈。572Please respect copyright.PENANAY79G14ggKK
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這亦證明,PTHrP蛋白質只是導致癌症時候肌肉萎縮的其中一道組件,還需要癌細胞另外的付出才可達成。572Please respect copyright.PENANAcVAExBU4pd
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癌症所帶來的CAC現象,會導致藥物對其他正常器官出現更強烈的副作用及毒性。這變相需要降低用藥的劑量作出配合,因而減低了滅癌的效率。572Please respect copyright.PENANATVPX2Kg46D
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因此,現今科學家亦在努力嘗試找出CAC的整套機制,務求找出有效的醫學方法制止CAC的產生。572Please respect copyright.PENANADVn5ADcCHT
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如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。572Please respect copyright.PENANAlj9ahSLb02
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Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc572Please respect copyright.PENANApFKKjeovTS
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同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。572Please respect copyright.PENANAVIAPyIdBqW
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基於WhatsApp/Facebook等問題,IG將不會再作更新,只會寄居本土LIHKG及Penana。572Please respect copyright.PENANA5LjR3O5UcD
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Ref1:https://www.nature.com/articles/nature13528572Please respect copyright.PENANAMgdgYTWUV6