不少的癌症病人均會出現體重及BMI急速下降的情況,肌肉會出現萎縮,脂肪組織亦有機會有所消耗,這現象稱之為Cancer-associated cachexia(CAC)。350Please respect copyright.PENANAeAfVW7IeMx350Please respect copyright.PENANAo3vLMYQ2Kc
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與厭食症不同的是,體重的流失並沒能依靠增加進食來進行完全填補。350Please respect copyright.PENANAumMzUgvq5c
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(圖2)CAC的形成,是腫瘤與身體多種器官互動後所得出的結果,箇中涉及新陳代謝及荷爾蒙的轉變。350Please respect copyright.PENANA3s5ECgAG9b350Please respect copyright.PENANAgdV1RcKrgO
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(圖3)從圖中所見,老鼠出現腫瘤約21日後,腿部肌肉出現萎縮,與人類的CAC現象吻合。350Please respect copyright.PENANAQoCYcHyj1A350Please respect copyright.PENANAWKafQ8exgK
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PTHrP是一種某類型的腫瘤釋放到血管的蛋白質,而往老鼠注射PTHrP蛋白質抗體的話,肌肉的萎縮程度亦有所緩和。350Please respect copyright.PENANAe1gts2Hx1A
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只可是,往健康老鼠注射PTHrP蛋白質的話,肌肉並不會貿然萎縮,而往出現腫瘤的老鼠注射PTHrP蛋白質的話,肌肉萎縮的程度反會更加劇烈。350Please respect copyright.PENANAAu5ySXycAu
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這亦證明,PTHrP蛋白質只是導致癌症時候肌肉萎縮的其中一道組件,還需要癌細胞另外的付出才可達成。350Please respect copyright.PENANAWiqCfoZIaY
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癌症所帶來的CAC現象,會導致藥物對其他正常器官出現更強烈的副作用及毒性。這變相需要降低用藥的劑量作出配合,因而減低了滅癌的效率。350Please respect copyright.PENANAwxU9k6HBjC
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因此,現今科學家亦在努力嘗試找出CAC的整套機制,務求找出有效的醫學方法制止CAC的產生。350Please respect copyright.PENANArC0fHaBigb
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基於WhatsApp/Facebook等問題,IG將不會再作更新,只會寄居本土LIHKG及Penana。350Please respect copyright.PENANAHvYsOX1ejF
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Ref1:https://www.nature.com/articles/nature13528350Please respect copyright.PENANAjkG1LJX0YL