不少的癌症病人均會出現體重及BMI急速下降的情況,肌肉會出現萎縮,脂肪組織亦有機會有所消耗,這現象稱之為Cancer-associated cachexia(CAC)。489Please respect copyright.PENANAV3I0vV53k3489Please respect copyright.PENANAT8REZNneey
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與厭食症不同的是,體重的流失並沒能依靠增加進食來進行完全填補。489Please respect copyright.PENANAovoyF5GRph
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(圖2)CAC的形成,是腫瘤與身體多種器官互動後所得出的結果,箇中涉及新陳代謝及荷爾蒙的轉變。489Please respect copyright.PENANA0dJXKrtjOh489Please respect copyright.PENANADzSbQwE83A
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(圖3)從圖中所見,老鼠出現腫瘤約21日後,腿部肌肉出現萎縮,與人類的CAC現象吻合。489Please respect copyright.PENANAbb8Z9ATTLi489Please respect copyright.PENANALibhyoy4uT
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PTHrP是一種某類型的腫瘤釋放到血管的蛋白質,而往老鼠注射PTHrP蛋白質抗體的話,肌肉的萎縮程度亦有所緩和。489Please respect copyright.PENANAoNeLm6CExX
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只可是,往健康老鼠注射PTHrP蛋白質的話,肌肉並不會貿然萎縮,而往出現腫瘤的老鼠注射PTHrP蛋白質的話,肌肉萎縮的程度反會更加劇烈。489Please respect copyright.PENANAnBi54AAowF
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這亦證明,PTHrP蛋白質只是導致癌症時候肌肉萎縮的其中一道組件,還需要癌細胞另外的付出才可達成。489Please respect copyright.PENANAoDhTN3hutJ
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癌症所帶來的CAC現象,會導致藥物對其他正常器官出現更強烈的副作用及毒性。這變相需要降低用藥的劑量作出配合,因而減低了滅癌的效率。489Please respect copyright.PENANAdMFqMFdpOr
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因此,現今科學家亦在努力嘗試找出CAC的整套機制,務求找出有效的醫學方法制止CAC的產生。489Please respect copyright.PENANAInT37NRwNC
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Ref1:https://www.nature.com/articles/nature13528489Please respect copyright.PENANA0xRz0dEXoP