真菌感染(Fungi Infection)約引致全球每年約二百萬人的死亡,而現今對抗真菌(Fungi)的藥物類別主要共分為三大類別。672Please respect copyright.PENANA4N55lCdR2W672Please respect copyright.PENANAi63ZDUMEdb
672Please respect copyright.PENANAzO6SUeJ9Q4
(圖2)三大類別的藥物機制雖有不同,但最終目的均是透過破壞真菌的外層結構來抑制其生長。672Please respect copyright.PENANA0apU6c9Jdo672Please respect copyright.PENANAxhRm3Itomy
672Please respect copyright.PENANA0KmCRw0mQO
1.Azole672Please respect copyright.PENANAIRm3tfingU
抑制構成細胞膜的Ergosterol產生672Please respect copyright.PENANAoBI72gHS29
2. Polyene672Please respect copyright.PENANAidYLCbEdTe
消耗細胞膜的Ergosterol672Please respect copyright.PENANANat8rgLmnn
3. Echinocandins672Please respect copyright.PENANA0ILghUjPhx
抑制構成細胞外層的糖分組織產生672Please respect copyright.PENANAgAhGHGqaKo
672Please respect copyright.PENANAPp0Thhzq5e
672Please respect copyright.PENANAOhhHRby6Gb
(圖3)然而,現今出現了某一類別的Candida auris,上述三款的藥物均對它無法作出顯著功效。672Please respect copyright.PENANAnPwzQhQLlf672Please respect copyright.PENANA7vF8aMXfWN
672Please respect copyright.PENANAcrjZLUXAro
它能夠透過血液循環系統走進全身各部位,引發感染。672Please respect copyright.PENANAiLmFWS5kRB
672Please respect copyright.PENANAnIGKYUwxfY
就在2018年,英國急症室病人出現大規模Candida auris的感染,後來證實為共用探熱針所致(Ref1)。672Please respect copyright.PENANARTpfQsDNQ2
672Please respect copyright.PENANAoBZLDb0xkg
(圖4)有科學家近日發表文章(Ref2),在居住在深海生物的微生物中分離出命名為Turbinmicin的天然物質。672Please respect copyright.PENANAoBbjS4PYIe672Please respect copyright.PENANAe2mL7vDHJH
672Please respect copyright.PENANAFy6p0TNSvV
Turbinmicin能有效抑制不同真菌品種,包括Candida auris。672Please respect copyright.PENANA2yHYzovzxP
672Please respect copyright.PENANAmUmk7QDXNS
它的機制乃為影響內部的蛋白質運輸,與現今三類抑制外圍結構的機制不同,可能因而能夠擊殺得到抵擋現今三大類藥物的Candida auris。672Please respect copyright.PENANAIYp1U5gl0p
672Please respect copyright.PENANArNINjZtkvG
它並不會對人體的紅血球造成傷害,高劑量的使用亦沒有對老鼠做成影響,同時亦能治理Candida auris在老鼠體內所引發的感染。672Please respect copyright.PENANAMRG884gE0Z
672Please respect copyright.PENANABLtIeuIZwf
但會否引起副作用或其他問題,還需要進一步的研究確實後,才能開啟人類試驗。672Please respect copyright.PENANAA4FVsSlEqN
672Please respect copyright.PENANAgkcHrDFXLk
672Please respect copyright.PENANAr0vWe8PZK4
深海一直是未被深入發掘的領域,這一次找到對抗耐藥真菌曙光,日後可能會繼續有意想不到的驚喜。672Please respect copyright.PENANAtClvKlVWZH
672Please respect copyright.PENANAMSb0Qjn7jZ
如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。672Please respect copyright.PENANAGBMhzDiY8c
672Please respect copyright.PENANA7ViUsSLwWU
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc672Please respect copyright.PENANAHhvr8kX60p
672Please respect copyright.PENANAdC2o1sLLkE
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。672Please respect copyright.PENANAAfeXZfly8A
672Please respect copyright.PENANAR1eV0Mca9D
Link:672Please respect copyright.PENANAIq3kDpLUBa
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio672Please respect copyright.PENANA0JjV4zlnns
672Please respect copyright.PENANAEkaHZRprui
有興趣接收科學資訊的話,歡迎follow IG: potatopigtongue。672Please respect copyright.PENANAJCsqbDN4rc
672Please respect copyright.PENANAZG01maD3JC
https://www.instagram.com/potatopigtongue/672Please respect copyright.PENANAPTWdoPWPnc
672Please respect copyright.PENANAfmHQbWNROS
Ref1:https://www.nejm.org/doi/full/10.1056/NEJMc1900112672Please respect copyright.PENANAJVZCWVc1CV
Ref2:https://science.sciencemag.org/content/370/6519/974672Please respect copyright.PENANAOpaFlCX8jG