化療殺滅癌細胞的效率非常參差,有些情況更反而會導致癌細胞加速生長,究竟為何會這樣?500Please respect copyright.PENANAxxvwTRMN18500Please respect copyright.PENANAG4oa4sRXju
500Please respect copyright.PENANAxkcKpqaqEI
(圖2)使用化療藥物過後,某些癌細胞的確是會歸西死亡。500Please respect copyright.PENANAZFA2m7HiyG
而細胞死亡的方式有好幾種,其中兩種為Apoptosis及Necrosis。500Please respect copyright.PENANA7BcxZOTXeJ500Please respect copyright.PENANAk65m9irmBC
500Please respect copyright.PENANAfhTmrQhcdd
如圖中所見,進行Apoptosis的細胞會呈完整球狀,屍體相對的體積較大。500Please respect copyright.PENANAhY8S0fyP7K
而進行Necrosis的細胞則會分成為不規則的碎塊,體積亦較細。500Please respect copyright.PENANAgGOD0FHZya
500Please respect copyright.PENANAmvsvSfj34S
(圖3)形象化來說,Apoptosis就是曲奇餅,而Necrosis就是曲奇餅碎。500Please respect copyright.PENANAw7ZO50JPP1500Please respect copyright.PENANAWwdSUBtxJy
500Please respect copyright.PENANAMIOCsTFZIn
500Please respect copyright.PENANAcYmt31Iatu
(圖4)癌細胞被化療藥物殺死後,若進行Necrosis,鄰近沒受化療影響的癌細胞便會啟動一道名為Macropinocytosis的機制,將死亡的細胞吞噬,作營養供用使自己繼續成長,抵禦化療藥物所帶來的困境。500Please respect copyright.PENANApX2wgeh9YS500Please respect copyright.PENANAnvk5cGmTRV
500Please respect copyright.PENANAiVBbr3u18T
但細胞進行Apoptosis的話,因屍體體積過大,鄰近的細胞便不能把其吞噬。500Please respect copyright.PENANATdz8A8NR7D
500Please respect copyright.PENANA30AqGSRCUW
並不是所有癌細胞亦能懂得施展Macropinocytosis,而整個機制學界亦在模索之中,只知道某些基因如PI3K或Ras進行突變的話,Macropinocytosis發生的機率亦會較大。500Please respect copyright.PENANAwsLZiJ39nn
500Please respect copyright.PENANAtDzPLTI1fx
若能掌握整套機制及研發藥物制止Macropinocytosis的發生,並在化療藥物其間同時使用,便能壓抑癌細胞吞噬死亡細胞的機制,大大增加化療的效果。500Please respect copyright.PENANAjiQ6aCswLO
500Please respect copyright.PENANAAqAJLhJeSa
500Please respect copyright.PENANAH3Jbxx4Mjf
如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。500Please respect copyright.PENANA30IrArDv3i
500Please respect copyright.PENANAF9h4lFTSDO
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc500Please respect copyright.PENANASnT8MOXoVC
500Please respect copyright.PENANAX2GcefAeTI
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。500Please respect copyright.PENANAo39hr1f9cI
500Please respect copyright.PENANAfSEb6V4cxM
Link:500Please respect copyright.PENANAaTGhdYafyz
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio500Please respect copyright.PENANAW9BZ2jnljh
500Please respect copyright.PENANA1tzKNJt00B
500Please respect copyright.PENANApQhMCde81J
基於WhatsApp/Facebook等問題,IG將不會再作更新,只會寄居本土LIHKG及Penana。500Please respect copyright.PENANAfeV9AHArN1
500Please respect copyright.PENANAZ0b7QTbGhX
Ref1:https://www.nature.com/articles/s41467-020-14928-3500Please respect copyright.PENANAfOMMhagPqI