化療殺滅癌細胞的效率非常參差,有些情況更反而會導致癌細胞加速生長,究竟為何會這樣?356Please respect copyright.PENANA16bpbow2AA356Please respect copyright.PENANAibTSlmR3aZ
356Please respect copyright.PENANAXOPRGIrU60
(圖2)使用化療藥物過後,某些癌細胞的確是會歸西死亡。356Please respect copyright.PENANAsuFYKXfhfd
而細胞死亡的方式有好幾種,其中兩種為Apoptosis及Necrosis。356Please respect copyright.PENANABcuYHcUhwM356Please respect copyright.PENANASaxNQv4G3r
356Please respect copyright.PENANA97uOFkOmv3
如圖中所見,進行Apoptosis的細胞會呈完整球狀,屍體相對的體積較大。356Please respect copyright.PENANA6FxC9DIUwj
而進行Necrosis的細胞則會分成為不規則的碎塊,體積亦較細。356Please respect copyright.PENANA6NJF0ZyDKZ
356Please respect copyright.PENANAG33i8WjLFT
(圖3)形象化來說,Apoptosis就是曲奇餅,而Necrosis就是曲奇餅碎。356Please respect copyright.PENANAWUhpVRT8gk356Please respect copyright.PENANA93QImDWNoI
356Please respect copyright.PENANAlxZ4b0kZf4
356Please respect copyright.PENANAEf6nw0DWkv
(圖4)癌細胞被化療藥物殺死後,若進行Necrosis,鄰近沒受化療影響的癌細胞便會啟動一道名為Macropinocytosis的機制,將死亡的細胞吞噬,作營養供用使自己繼續成長,抵禦化療藥物所帶來的困境。356Please respect copyright.PENANAGrGLo345ZI356Please respect copyright.PENANADk4HLET76P
356Please respect copyright.PENANAfmFzZPRoAq
但細胞進行Apoptosis的話,因屍體體積過大,鄰近的細胞便不能把其吞噬。356Please respect copyright.PENANARWXMOsAf5M
356Please respect copyright.PENANAOICCdTbbS1
並不是所有癌細胞亦能懂得施展Macropinocytosis,而整個機制學界亦在模索之中,只知道某些基因如PI3K或Ras進行突變的話,Macropinocytosis發生的機率亦會較大。356Please respect copyright.PENANAJMU4bRbeMu
356Please respect copyright.PENANAx5YDV9IkpB
若能掌握整套機制及研發藥物制止Macropinocytosis的發生,並在化療藥物其間同時使用,便能壓抑癌細胞吞噬死亡細胞的機制,大大增加化療的效果。356Please respect copyright.PENANAD3scDajL0O
356Please respect copyright.PENANAlhrjC2vf1f
356Please respect copyright.PENANAXlBE9NrOJT
如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。356Please respect copyright.PENANAZ8H95frX5v
356Please respect copyright.PENANA4vMzjldWHC
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc356Please respect copyright.PENANAwUVnOFATAt
356Please respect copyright.PENANAFUmLMUyQjm
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。356Please respect copyright.PENANAgLTlXTcJZW
356Please respect copyright.PENANAjTUCy8cKH6
Link:356Please respect copyright.PENANAjqfSdrplWs
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio356Please respect copyright.PENANAsNlSOE9nGH
356Please respect copyright.PENANA8agBpAhSQh
356Please respect copyright.PENANAzCnoFaaIZT
基於WhatsApp/Facebook等問題,IG將不會再作更新,只會寄居本土LIHKG及Penana。356Please respect copyright.PENANAS8AXEmC9OL
356Please respect copyright.PENANA6ahWz78Dgj
Ref1:https://www.nature.com/articles/s41467-020-14928-3356Please respect copyright.PENANADkckfjmJYR