藥物的效用有時候因人而異,其中一道原因,可以歸究於每個人體內的腸道細菌品種有所不同所致。487Please respect copyright.PENANAQhCqbchbIm487Please respect copyright.PENANAgDhsLMQNiS
487Please respect copyright.PENANA5rIeQdkvKk
(圖2)口服藥物要抵達血管循環系統的話,無可避免將會途經我們的腸道。487Please respect copyright.PENANAXqBbWNIRYK
而我們腸道的細菌有能力改造或代謝藥物,因而改變藥物結構及其效用。487Please respect copyright.PENANAwrZFrdRAyN487Please respect copyright.PENANAm4MU1V0p0u
487Please respect copyright.PENANA4OanQxEMOD
487Please respect copyright.PENANAyF9fHj62oM
487Please respect copyright.PENANA3HFfqLkWpR
(圖3)有科學家找來人體最為常見的76種腸道細菌品種,與271款不同界別常用的藥物共同放在一起12小時。487Please respect copyright.PENANAdK5gMEJvFn487Please respect copyright.PENANAC0o24BEBa3
487Please respect copyright.PENANAdCMPdgMEs8
最終發現,271款藥物中,有多達176款藥物的濃度在被至少一種腸道細菌影響下,濃度減少了20%;487Please respect copyright.PENANAeZJoVQpAGa
而這些腸道細菌品種每款可以代謝11-95款藥物不等。487Please respect copyright.PENANASYYeTH8HHr
487Please respect copyright.PENANAGZz2nvwJv8
用上老鼠作動物模型,科學家更能找出所屬細菌哪一條基因負責消化/代謝藥物,引證腸道細菌影響藥物吸收的理念。487Please respect copyright.PENANA10xkui4hF1
487Please respect copyright.PENANAapcc7P6BWL
倘若你腸道恰巧住有細菌A,而細菌A又有能力吸收你所口服的藥物,那麼藥效便有可能會大大減低。487Please respect copyright.PENANA3GhJZYwUGg
487Please respect copyright.PENANAKsq6ZRYplg
血液注射而非口服的藥物將有機會不受此限,因為藥物並不需一定要經過腸道裡頭。487Please respect copyright.PENANA25vM31OGmX
487Please respect copyright.PENANAX1BBgfPcss
487Please respect copyright.PENANA6HlZm34tmM
如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。487Please respect copyright.PENANA709ZbBaTVE
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Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc487Please respect copyright.PENANAjEDpyB3lrn
487Please respect copyright.PENANATfmnJo3X4z
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。487Please respect copyright.PENANAhwQvD0BKr6
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Link:487Please respect copyright.PENANAqo3HAxvo3N
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio487Please respect copyright.PENANABhSp6cNQeO
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除非Facebook及IG重開侵侵的account,否則我的IG將不會再作更新,只會寄居本土LIHKG及Penana。487Please respect copyright.PENANAdRPXhrnJnh
487Please respect copyright.PENANA5rxzZ9zaNr
Ref1:https://www.nature.com/articles/s41586-019-1291-3487Please respect copyright.PENANAx5qMo1rkvE