口腔所進食的食物，途經各器官後便會來到小腸，絕大部份的營養最終將透過空腸(Jejunum)進入血液循環系統裡頭，再分配予各身體細胞；576Please respect copyright.ＰＥＮＡＮＡawOAFVOVJd
我們的空腸內壁擁有著絨毛狀的結構(villi)，將大大增加遇上及吸取營養的效率，以達其消化及吸收營養的重任。576Please respect copyright.ＰＥＮＡＮＡGM6qmJwzAA
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（圖2）食得是褔，著得是祿。576Please respect copyright.ＰＥＮＡＮＡTE7oPpfjDU
患有短腸症候群(Short Bowel Syndrome，每年約每一百萬個小童便有三名患者)或其他腸道疾病問題的兒童，因著空腸長度有機會出現過短的狀況，很多時候下並沒能夠吸取足夠營養支撐正常成長。576Please respect copyright.ＰＥＮＡＮＡ0Q2aRLy5E6
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嚴重的情況，便需要進行器官移植。576Please respect copyright.ＰＥＮＡＮＡhEzYHZyfXG
576Please respect copyright.ＰＥＮＡＮＡdc2AKaUQky
只不過，適用的器官並不是話來就來，而且亦有不少個案出現器官排斥問題，引發一連串的併發症。576Please respect copyright.ＰＥＮＡＮＡcjD7GX1LOu
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（圖3）為了紓困現狀，有科學家在近日發表文章（Ref1)，嘗試提出方法解決現時所面對的困局–576Please respect copyright.ＰＥＮＡＮＡpEW6WUGci7
576Please respect copyright.ＰＥＮＡＮＡZho2rIGuFl
抽取患者的腸道細胞，以體外的方式在實驗室進行培植，製造出新一條的空腸。576Please respect copyright.ＰＥＮＡＮＡB2ZhY5DtDj
而因著器官是由患者本身的細胞而來，出現排斥的機會亦順然大幅度能夠減低下來。576Please respect copyright.ＰＥＮＡＮＡ8zgqb4fytc
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576Please respect copyright.ＰＥＮＡＮＡBPQ7T10WQE
這次研究中，他們找來了28名歲數從3個月大至15歲的小童，從某部份的病人體內拿取2mm左右的腸道樣本，在實驗室內培植兩個月左右的時間，得出俱備空腸功能的類器官576Please respect copyright.ＰＥＮＡＮＡV4p2q01AfJ
(Organoid);576Please respect copyright.ＰＥＮＡＮＡ5GruwUKrww
576Please respect copyright.ＰＥＮＡＮＡcvzZkekdjH
類器官可看成為半完成物，有著器官的關鍵功能，但外貌及個別特徵始終與完整器官差天共地。576Please respect copyright.ＰＥＮＡＮＡicJtAXGhAZ
576Please respect copyright.ＰＥＮＡＮＡVpgAo83lP1
同時間，他們亦拿取病人腸道一小節，把所有的細胞清除得一乾二淨，用作為日後移植用的基座(Scaffold)。576Please respect copyright.ＰＥＮＡＮＡNe4hMLrpdE
之所以要沿用病人的腸道作為基座，原因是病人腸道本質上有著引導類器官繼續發展成型的能力，而這種本質現今科技上還沒能完完全全利用其他物料成功複製出來。576Please respect copyright.ＰＥＮＡＮＡD06zUvn0M5
576Please respect copyright.ＰＥＮＡＮＡJdGI6bKYjU
他們把類器官培植在基座上一段時間後，再嘗試移植到老鼠身體上，箇中亦證實得到類器官在老鼠體內擁有發展成為腸道的能力。576Please respect copyright.ＰＥＮＡＮＡa6lJxr7lFx
576Please respect copyright.ＰＥＮＡＮＡVT70zMiQAI
將類器官移植回到病人體內這一步，無疑還有一段距離才能實行。576Please respect copyright.ＰＥＮＡＮＡ6XrzTWekOk
但這研究在老鼠身上所得出的成果，至少證實得到這個大方向是有著實際應用上的可行性，並非紙上談兵風花雪月，而是為日後實際套用在病人方面上奠下了一重要的理論基礎。576Please respect copyright.ＰＥＮＡＮＡdnrK10tqAu
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如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。576Please respect copyright.ＰＥＮＡＮＡgweCdkivPD
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Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc576Please respect copyright.ＰＥＮＡＮＡgQkGrX6Va0
576Please respect copyright.ＰＥＮＡＮＡtqz9Bgm2hm
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。576Please respect copyright.ＰＥＮＡＮＡIfSc9lpsik
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Link:576Please respect copyright.ＰＥＮＡＮＡKJI51BJZfD
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio576Please respect copyright.ＰＥＮＡＮＡZbYYCrvn4P
576Please respect copyright.ＰＥＮＡＮＡoh6chqeXew
576Please respect copyright.ＰＥＮＡＮＡBBkV5nErlZ
有興趣接收科學資訊的話，歡迎follow IG: potatopigtongue。576Please respect copyright.ＰＥＮＡＮＡypyKcEwu1c
576Please respect copyright.ＰＥＮＡＮＡ8AIac3Xg5l
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Ref1:https://www.nature.com/articles/s41591-020-1024-z576Please respect copyright.ＰＥＮＡＮＡS9gfMUGntN
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