此篇文章並非意圖貶損任何癌症的治療方法,純粹是轉述一宗失敗個案及其原因,探討從失敗中學習的過程。557Please respect copyright.PENANA449yBHqcOi
557Please respect copyright.PENANAGlCcDfKIk4
利用免疫治療法來對抗癌症,早前我們已經花了不少篇幅講述。557Please respect copyright.PENANAailoRBnR1w
延伸閱讀:https://www.penana.com/article/500206557Please respect copyright.PENANAXGDcDEJbxv557Please respect copyright.PENANAZZLuvOm1u3
557Please respect copyright.PENANAZNwoEzcXXa
CAR T cell治療法,就是利用基因改造技術在免疫細胞外部加插辨識細胞的組件,引導它們更有效率殲滅對應的細胞;557Please respect copyright.PENANAUvXBkyx77w
在這個層面上,亦即是癌細胞。557Please respect copyright.PENANAOGURS4gdMy
557Please respect copyright.PENANARkmf3YwDbk
(圖2)2010年,一名39歲女士患上腸癌,久經不同款式化療亦未見成效,故此便嘗試當時候較為新穎的CAR T cell 療法。557Please respect copyright.PENANAJiPR47hIl7557Please respect copyright.PENANAfaFXbUQ1gX
557Please respect copyright.PENANApF7HmohoQm
她的腸癌細胞表面被診斷出持有非常多的ERBB2蛋白質,所以其治療的方式便是從她身上取得免疫細胞,再在實驗室裡培植加插能夠辨認ERBB2蛋白質的CAR T cell,再以將這些CAR T cell注入她體內,盼望這些CAR T cell會殲滅腸癌細胞。557Please respect copyright.PENANAAJPq0dxTsd
557Please respect copyright.PENANABlkZ9OOQWM
557Please respect copyright.PENANAUdsNEuXes3
(圖3)不幸的是,注入CAR T cell後的15分鐘,她出現呼吸困難等症狀,隨之亦送入ICU作出治療,唯5日後亦與世祥辭。557Please respect copyright.PENANABwGj4v3trH557Please respect copyright.PENANAZdcVOGZEvF
557Please respect copyright.PENANAxjVqB2isQk
最後經驗屍及分析各種數據後,相信是因為肺部含有微量ERBB2蛋白質,在抵達癌細胞位置前,那些CAR T cell率先與持有ERBB2的肺部細胞結合,產生過量的免疫反應,引致肺部器官發炎及衰竭,導致氧氣沒能輸送至各器官位置。557Please respect copyright.PENANAwjBezGvQA2
557Please respect copyright.PENANAROxgewYrgN
在這手術進行之前,亦有不少針對ERBB2的CAR T cell人體試驗,箇中並沒有發生相同症狀。557Please respect copyright.PENANA6orPEDKRKu
557Please respect copyright.PENANAFtkZ5HWoaP
這相信是因為是次手術為了希望能夠順利殲滅癌細胞,其注入的T cell數量被以往實驗過多,因此就連ERBB2含量不多的肺部細胞亦被牽涉在內。557Please respect copyright.PENANAPRMfGOBbN6
557Please respect copyright.PENANAJrDK46W3rN
無論如何,從這之經驗中可得知,ERBB2顯然並不是一道針對癌細胞的理想對象。557Please respect copyright.PENANA1JxxeY8uw4
557Please respect copyright.PENANAYwhUui3EQr
557Please respect copyright.PENANAqq5WO2Hn8N
557Please respect copyright.PENANAc2H23yqInI
557Please respect copyright.PENANAGcGNd2E3r2
557Please respect copyright.PENANAa9N8KNiB9T
如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。557Please respect copyright.PENANAeRvqUrLKih
557Please respect copyright.PENANAlTUQm47yCZ
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc557Please respect copyright.PENANAtslcDVDEIZ
557Please respect copyright.PENANAYhCLZJd35d
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。557Please respect copyright.PENANAXvbS9c9OP2
557Please respect copyright.PENANAxUrxs2VrtK
Link:557Please respect copyright.PENANAoe7uq3wGkB
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio557Please respect copyright.PENANArvxK698yIt
557Please respect copyright.PENANABZ6RHBnR4m
557Please respect copyright.PENANAZX1vcvwRLb
除非Facebook及IG重開侵侵的account,否則我的IG將不會再作更新,只會寄居本土LIHKG及Penana。557Please respect copyright.PENANA0hHA5A90pl
557Please respect copyright.PENANAUqGcQwsSkf
Ref1:https://pubmed.ncbi.nlm.nih.gov/20179677/
557Please respect copyright.PENANAjsVeYkvAlE