當細胞裡頭出現多餘或者已受損毀的物質，又或者是細胞面臨營養不足的情況，細胞便會啟動名為自噬(Autophagy)的機制，依靠溶酶體(lysosome)將物質消化成為蛋白質/糖份/脂肪，供自己能量或物質所需。612Please respect copyright.ＰＥＮＡＮＡYtd7JQzBLr
612Please respect copyright.ＰＥＮＡＮＡc84SIT6k6k
612Please respect copyright.ＰＥＮＡＮＡxYV5ccLZrz
早前亦有提及Cancer-associated fibroblasts如何利用自噬(Autophagy)幫助癌細胞生長。612Please respect copyright.ＰＥＮＡＮＡV2n1uq1did
三十秒科學–癌細胞也會自肥？612Please respect copyright.ＰＥＮＡＮＡkUp6ocpAgU
- 分享自 LIHKG 討論區612Please respect copyright.ＰＥＮＡＮＡ0d3fM3x2MP
https://lih.kg/hgfcNS612Please respect copyright.ＰＥＮＡＮＡ80lx2J9bts
612Please respect copyright.ＰＥＮＡＮＡpZ5ncOdzvX
612Please respect copyright.ＰＥＮＡＮＡ8mhbvk9Edv
(圖2)自噬(Autophagy)機制能夠讓細胞在營養不足的情況摧毀多餘的物質，使自己得以在困局下苟延殘喘。612Please respect copyright.ＰＥＮＡＮＡ63IQo6alEU
612Please respect copyright.ＰＥＮＡＮＡXoKu569PZe
612Please respect copyright.ＰＥＮＡＮＡsAh2hrlyeY
情形就如人們債務纏身而又沒有收入抵債的時候，只好變賣自己所持有的資產，化成現金抵償。612Please respect copyright.ＰＥＮＡＮＡQ7YXgG8fgy
612Please respect copyright.ＰＥＮＡＮＡRwsIQ9Jtb4
由此可以想像，這是一道治標不治標的方法。612Please respect copyright.ＰＥＮＡＮＡwhHvZOkxYB
當長期沒有營養流入細胞，而細胞再也沒有多餘物質進行自噬的時候，細胞便會啟動自行滅亡的機制。612Please respect copyright.ＰＥＮＡＮＡqgWFiNOq3F
612Please respect copyright.ＰＥＮＡＮＡH1W43Skh0T
612Please respect copyright.ＰＥＮＡＮＡwRqYScBFhw
(圖3)如果催谷癌細胞不斷進行自噬作用的話，促使它們啟動自行滅亡的機制，那豈不是殺滅它們的一道妙計?612Please respect copyright.ＰＥＮＡＮＡDzDoAC2VIe
612Please respect copyright.ＰＥＮＡＮＡUyEf5sVAsV
612Please respect copyright.ＰＥＮＡＮＡELPDz8dgQ4
很遺憾地，各款癌細胞對於自噬作用的依賴及抗性均有所不同，難以就此單一針對自噬作用來消滅癌細胞。612Please respect copyright.ＰＥＮＡＮＡxEOwbavGlE
612Please respect copyright.ＰＥＮＡＮＡ3822Lk0duw
暫時較為統一的發現是，大多數的胰臟癌細胞均非常依賴自噬作用來維持自己的生長速度。612Please respect copyright.ＰＥＮＡＮＡVrxCpoQY9G
612Please respect copyright.ＰＥＮＡＮＡexdrQChOwQ
在實驗室細胞模型及老鼠實驗中，若果對胰臟癌細胞使用抑制自噬作用的藥物，不但改變它們的新陳代謝，且可減慢癌細胞的生長速度，非常之有潛質成為對抗胰臟癌的其中一手段。612Please respect copyright.ＰＥＮＡＮＡ17AlHTx4k4
612Please respect copyright.ＰＥＮＡＮＡ1byC0QHPRU
612Please respect copyright.ＰＥＮＡＮＡLLCU7JaIg6
如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。612Please respect copyright.ＰＥＮＡＮＡWj184KoEp4
612Please respect copyright.ＰＥＮＡＮＡ5jluQegxs8
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc612Please respect copyright.ＰＥＮＡＮＡkqQCq6DOgu
612Please respect copyright.ＰＥＮＡＮＡsr9jxVCBzZ
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。612Please respect copyright.ＰＥＮＡＮＡ2DLEnU8eNO
612Please respect copyright.ＰＥＮＡＮＡoGxHq7hDSL
Link:612Please respect copyright.ＰＥＮＡＮＡUgAE8gMf06
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio612Please respect copyright.ＰＥＮＡＮＡO1hGr0GLzR
612Please respect copyright.ＰＥＮＡＮＡKk6jR4inB6
612Please respect copyright.ＰＥＮＡＮＡdBc66nJVKc
除非Facebook及IG重開侵侵的account，否則我的IG將不會再作更新，只會寄居本土LIHKG及Penana。612Please respect copyright.ＰＥＮＡＮＡ9aPFJUKU7o
612Please respect copyright.ＰＥＮＡＮＡf7vwW7718r
Ref1:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3070934/612Please respect copyright.ＰＥＮＡＮＡTLdaJs4qCu
Ref2:https://cancerres.aacrjournals.org/content/66/19/9349.long
1
0
