免疫細胞中,有一類別名為Natural Killer Cell(NK cell)。542Please respect copyright.PENANAgv3pPRbgCO542Please respect copyright.PENANAgVQEjKVZ6a
它們並不需要抗體的輔助,能夠直接與受病毒感染的細胞或癌細胞接觸,並且能夠在對方的表面開拓出微孔,繼而再將特定的蛋白酶注入對方內部,導致對方啟動自行滅亡的機制。542Please respect copyright.PENANAo9zaj8J8Ju
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(圖2)NK cell及癌細胞表面均有著形形式式的蛋白質,雙方表面某部分的蛋白質會互相結合,某些組合會促進NK cell啟動殺滅對方的機制(如圖中+號),而某些組合(圖中-號)則會抑制會NK cell的啟動。542Please respect copyright.PENANACJJL3Rc4YX542Please respect copyright.PENANABirDdR0Lv2
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這些加加減減組合的互動,最終將會主宰NK cell會否殺滅對方。542Please respect copyright.PENANAVtQTgn5cw2
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(圖3)除了加加減減組合的互動,那些表面蛋白質所在的位置亦會影響NK cell殺滅對方的效率。542Please respect copyright.PENANAVDKKlaOqsO542Please respect copyright.PENANAgIAwM7G086
有研究人員將具有促進NK cell啟動殺滅對方的機制的蛋白質附在玻璃上,分別製作圖餅形狀(圖上)及冬甩形狀(圖下),雖兩者表面上的蛋白質數量均一模一樣,但NK cell停留在圖餅形的時間卻比冬甩形狀的時間相對上較長。542Please respect copyright.PENANAkunRU06s8Q
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之所以有這樣的差別,相信是NK cell較多時候無法完整地包圍著冬甩形狀,因此脫離對方的機率亦隨之較高。542Please respect copyright.PENANAxSYcSytQZ4
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換句話說,就算對方表面的蛋白質含量一樣,若然所在位置並不是均整地呈現在每一個角落,亦將有機會影響NK cell殺滅的效率。542Please respect copyright.PENANABKgpmAxgNo
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Ref1:https://www.frontiersin.org/articles/10.3389/fimmu.2015.00202/full542Please respect copyright.PENANA44ogAaejau
Ref2:https://stke.sciencemag.org/content/14/684/eabe2740
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