此為上集的補充篇:三十秒科學–癌症所導致的體重流失461Please respect copyright.PENANA2j2aOXFyfG
https://lih.kg/2397914461Please respect copyright.PENANAzXYgZ4uRJc
461Please respect copyright.PENANA99L2rcJh31
癌症惡病質(cancer cachexia)泛指因癌症而導致的體重流失,大部份情況下主要是由喪失肌肉所致,並沒法依靠進食來填補其喪失。461Please respect copyright.PENANAdFFUMXPoEn461Please respect copyright.PENANAvP61vFdbPI
461Please respect copyright.PENANA2sKlTkVsw7
在眾多癌症之中,高達接近70%的胰臟癌病人會出現cancer cachexia,總體重的損失在六個月內可高達25%。461Please respect copyright.PENANAWHfQtTGmAe
相反,患上前列腺癌的病人僅只有約10%的人出現cancer cachexia。461Please respect copyright.PENANAtjJK80JNMT
461Please respect copyright.PENANA03UBXBtYED
461Please respect copyright.PENANAIloNtJbGoH
(圖2)病人出現cancer cachexia的話(以體重損失超過10%為指標),其生存的機率亦會因而顯著下降。461Please respect copyright.PENANA1A4osAVBZx461Please respect copyright.PENANAcKTDnnbrQn
461Please respect copyright.PENANATYqTWmWbQI
正因如此,若能了解其cancer cachexia機制並加以針對的話,將會是抵抗癌症的其中一道手法。461Please respect copyright.PENANAH2lqMuZyha
461Please respect copyright.PENANARwjxq5x0BX
461Please respect copyright.PENANAIxJnZyJdeI
(圖3)癌細胞所導致的體重流失,主要是由肌肉喪失所致。461Please respect copyright.PENANAGW5STLVuzW
而當我們的肌肉受到傷害或撕裂的時候,裡頭的幹細胞以及圖中所指的細胞將會出手幫忙製造肌肉,填補其損失。461Please respect copyright.PENANAlH6bhoFmGe461Please respect copyright.PENANAA0pGgnozzf
461Please respect copyright.PENANADmWonEraFT
461Please respect copyright.PENANA9Nlhqw89Os
癌細胞的厲害之處就是能夠釋出物質經由血管到達肌肉,誘導肌肉出現受傷情況之餘,並同時阻止肌肉幹細胞進行重生,因而導致肌肉流失情況發生。461Please respect copyright.PENANAjP8YVJW2Ih
461Please respect copyright.PENANADIjLgFgoou
癌細胞之所以這樣做,其中的一道推論是希望透過破壞肌肉而使血液間的氨基酸(蛋白質)含量增加,然後借助肝臟把這些氨基酸轉變成糖份,再由血液循環系統輸送給自身所用。461Please respect copyright.PENANAG4grqelHBh
461Please respect copyright.PENANAyvJOH9az5S
因著胰臟癌病人出現cancer cachexia的機率較高,有不少科學家均就此利用老鼠胰臟癌模型來研究cancer cachexia的機制。461Please respect copyright.PENANAccnk5f1ZBO
461Please respect copyright.PENANAsagWlNscLR
至今已至少找出得到,癌細胞所釋出的物質會導致肌肉幹細胞一種名為Pax7的蛋白質含量不斷上升,並因而導致肌肉幹細胞沒法子進行重組肌肉舉動。461Please respect copyright.PENANABvYhw08UVk
461Please respect copyright.PENANAJUnfu4wKIa
461Please respect copyright.PENANA7367KeYX7S
461Please respect copyright.PENANAW58zybzPmm
461Please respect copyright.PENANAvoWf9vTubm
如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。461Please respect copyright.PENANA3xntlrchtK
461Please respect copyright.PENANAAd3mYmVCmT
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc461Please respect copyright.PENANAJKz5okSOjU
461Please respect copyright.PENANAai9NhFbPEs
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。461Please respect copyright.PENANACDYqqWn7is
461Please respect copyright.PENANAzL2M5g5Uwb
Link:461Please respect copyright.PENANAI35kaGNm3h
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio461Please respect copyright.PENANAKElKdouavw
461Please respect copyright.PENANAgl6jXQYYjC
461Please respect copyright.PENANAXr3Y7Jwheq
除非Facebook及IG重開侵侵的account,否則我的IG將不會再作更新,只會寄居本土LIHKG及Penana。461Please respect copyright.PENANAMWVrYOgrIk
461Please respect copyright.PENANAeXYpByVSKU
Ref1:https://www.nature.com/articles/nrdp2017105461Please respect copyright.PENANA4zzFnyinHs