此為上集的補充篇:三十秒科學–癌症所導致的體重流失244Please respect copyright.PENANAcPACNyba7L
https://lih.kg/2397914244Please respect copyright.PENANAVnMyiwgfqQ
244Please respect copyright.PENANAgGQtwMLiNG
癌症惡病質(cancer cachexia)泛指因癌症而導致的體重流失,大部份情況下主要是由喪失肌肉所致,並沒法依靠進食來填補其喪失。244Please respect copyright.PENANAVEwTnr6JtW
244Please respect copyright.PENANAUjDXksnqNa
244Please respect copyright.PENANABkd3EF0aM9
在眾多癌症之中,高達接近70%的胰臟癌病人會出現cancer cachexia,總體重的損失在六個月內可高達25%。244Please respect copyright.PENANAGGbJBFfCYq
相反,患上前列腺癌的病人僅只有約10%的人出現cancer cachexia。244Please respect copyright.PENANADG4hXw6XJ9
244Please respect copyright.PENANAtCxQ4Bmsah
244Please respect copyright.PENANAkTsvGvAHtK
(圖2)病人出現cancer cachexia的話(以體重損失超過10%為指標),其生存的機率亦會因而顯著下降。244Please respect copyright.PENANA3SJ4BtTJT0
244Please respect copyright.PENANApVKb7CExxr
244Please respect copyright.PENANAZoFa4oVqBL
正因如此,若能了解其cancer cachexia機制並加以針對的話,將會是抵抗癌症的其中一道手法。244Please respect copyright.PENANAiaRU1Unbbo
244Please respect copyright.PENANAxHz0jJLPtU
244Please respect copyright.PENANAdKlXBr6qDM
(圖3)癌細胞所導致的體重流失,主要是由肌肉喪失所致。244Please respect copyright.PENANArHaGgHUaaB
而當我們的肌肉受到傷害或撕裂的時候,裡頭的幹細胞以及圖中所指的細胞將會出手幫忙製造肌肉,填補其損失。244Please respect copyright.PENANAw5g8J8QAyY
244Please respect copyright.PENANA0JyWL0CK8t
244Please respect copyright.PENANAMM64mjtHAM
244Please respect copyright.PENANAKjQeURgAQ5
癌細胞的厲害之處就是能夠釋出物質經由血管到達肌肉,誘導肌肉出現受傷情況之餘,並同時阻止肌肉幹細胞進行重生,因而導致肌肉流失情況發生。244Please respect copyright.PENANAStg6oScFT3
244Please respect copyright.PENANAvnFRVvqCas
癌細胞之所以這樣做,其中的一道推論是希望透過破壞肌肉而使血液間的氨基酸(蛋白質)含量增加,然後借助肝臟把這些氨基酸轉變成糖份,再由血液循環系統輸送給自身所用。244Please respect copyright.PENANARPZhKMj6q5
244Please respect copyright.PENANACBgKVH9AmF
因著胰臟癌病人出現cancer cachexia的機率較高,有不少科學家均就此利用老鼠胰臟癌模型來研究cancer cachexia的機制。244Please respect copyright.PENANAQVu4uYhCKq
244Please respect copyright.PENANAXHnUCqoGrk
至今已至少找出得到,癌細胞所釋出的物質會導致肌肉幹細胞一種名為Pax7的蛋白質含量不斷上升,並因而導致肌肉幹細胞沒法子進行重組肌肉舉動。244Please respect copyright.PENANAb5cvoRkkp6
244Please respect copyright.PENANAD8kaEpa3p9
244Please respect copyright.PENANAcUwaVtwgJN
244Please respect copyright.PENANAvGus97cqxU
244Please respect copyright.PENANAsVPz9g4lsj
如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。244Please respect copyright.PENANA9WDrXJTXKu
244Please respect copyright.PENANANxpqD9VmLg
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc244Please respect copyright.PENANAnfIs836KGo
244Please respect copyright.PENANAabmt2UhpDJ
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。244Please respect copyright.PENANARwGSkFRzTp
244Please respect copyright.PENANAa6Ua49LyM9
Link:244Please respect copyright.PENANAzCUn1nG2LP
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio244Please respect copyright.PENANAQeU2WzK74s
244Please respect copyright.PENANAAQhTyuUEYK
244Please respect copyright.PENANAGxQta4X0nw
除非Facebook及IG重開侵侵的account,否則我的IG將不會再作更新,只會寄居本土LIHKG及Penana。244Please respect copyright.PENANA9soPqUbHS8
244Please respect copyright.PENANAxiJxfjspbF
Ref1:https://www.nature.com/articles/nrdp2017105244Please respect copyright.PENANAy16GY5mEOW