黃金葡萄球菌這字眼,周不時亦會在新聞媒體聽得到。709Please respect copyright.PENANALQjzfGs2xO709Please respect copyright.PENANAU44DBvmbGL
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它之所以被冠以黃金這稱號,是因為它能夠製造大量金黃色的葡萄球菌黃素 (Staphyloxanthin),以及微量黃色化合物4,4‘-Diaponeurosporene。709Please respect copyright.PENANA9kTmx5JxGa
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(圖2)當細菌入侵腸道的時候,我們的腸道內壁細胞及前來救駕的免疫細胞會釋出微量雙氧水等的游離基(Reactive oxygen species),對細菌進行攻擊。709Please respect copyright.PENANAlAF7CTVgoC709Please respect copyright.PENANACECZxzPgzG
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但黃金葡萄球菌的金黃色葡萄球菌黃素及另外那種黃色化學物正是能夠中和游離基攻擊的色素,因此免疫系統所產生的游離基攻擊對它傷害不大。709Please respect copyright.PENANA1t1rJYqnKT
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然而,如果刪去製作色素的蛋白酶,「黃金」葡萄球菌失去抵擋游離基的手段,對宿主的感染力亦因而大大減低。709Please respect copyright.PENANA4cfTTqnA38
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(圖3)同時間,若將負責製造黃色色素的蛋白酶從黃金葡萄球菌轉移到另一款葡萄球菌,獲得了色素製作能力的它在老鼠身上所造成的感染傷害亦更之為強,引證色素對於細菌感染力的重要性。709Please respect copyright.PENANAc77TqGErBt709Please respect copyright.PENANA9OatoZcplf
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(圖4)再舉另外一道例子,Cryptococcus neoformans是一種真菌(fungus),709Please respect copyright.PENANAymjqN96zc1
它能夠製作黑色素(Melanin),亦即是上集所談及決定髮膚眼色的色素。709Please respect copyright.PENANAYywoxCSuqY709Please respect copyright.PENANAAtLMhkLExK
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黑色素除了跟金黃色葡萄球菌黃素一樣能夠抵擋游離基的攻擊外,其本身帶有負極的性質更能與兩隻帶有正極的常用抗真菌素(amphotericin B 及 caspofungin)結合,大大削弱藥物傷害真菌的能力。709Please respect copyright.PENANAPCnjXVeRkm
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延伸閱讀:709Please respect copyright.PENANAR93302PGAn
深入淺出–從深海生物中發掘出抗真菌藥物709Please respect copyright.PENANAbMF87LpjMd
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Ref1:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2743764/709Please respect copyright.PENANAJ8MxBTWr3d