黃金葡萄球菌這字眼,周不時亦會在新聞媒體聽得到。689Please respect copyright.PENANA8P02Droi4c689Please respect copyright.PENANAQvxiL2I7Zq
689Please respect copyright.PENANA2T1HSfXNQ7
它之所以被冠以黃金這稱號,是因為它能夠製造大量金黃色的葡萄球菌黃素 (Staphyloxanthin),以及微量黃色化合物4,4‘-Diaponeurosporene。689Please respect copyright.PENANAieo8vY85h5
689Please respect copyright.PENANAWhe2LfxURu
(圖2)當細菌入侵腸道的時候,我們的腸道內壁細胞及前來救駕的免疫細胞會釋出微量雙氧水等的游離基(Reactive oxygen species),對細菌進行攻擊。689Please respect copyright.PENANAO9i2jJAJnF689Please respect copyright.PENANA79qj9bDT7Y
689Please respect copyright.PENANAgzBiHOJQ5v
但黃金葡萄球菌的金黃色葡萄球菌黃素及另外那種黃色化學物正是能夠中和游離基攻擊的色素,因此免疫系統所產生的游離基攻擊對它傷害不大。689Please respect copyright.PENANAR49EvNZBl1
689Please respect copyright.PENANAv4j2JsK9FE
然而,如果刪去製作色素的蛋白酶,「黃金」葡萄球菌失去抵擋游離基的手段,對宿主的感染力亦因而大大減低。689Please respect copyright.PENANA4JOQy10dIv
689Please respect copyright.PENANAA48JNi07hn
(圖3)同時間,若將負責製造黃色色素的蛋白酶從黃金葡萄球菌轉移到另一款葡萄球菌,獲得了色素製作能力的它在老鼠身上所造成的感染傷害亦更之為強,引證色素對於細菌感染力的重要性。689Please respect copyright.PENANAsWi0Aqik2B689Please respect copyright.PENANAhkwpY32XCy
689Please respect copyright.PENANAdTUeMBtboS
(圖4)再舉另外一道例子,Cryptococcus neoformans是一種真菌(fungus),689Please respect copyright.PENANAeK5314XNSq
它能夠製作黑色素(Melanin),亦即是上集所談及決定髮膚眼色的色素。689Please respect copyright.PENANAKXNGaBxjOl689Please respect copyright.PENANAj6WlUoFOPL
689Please respect copyright.PENANAHKYsaz5zjC
黑色素除了跟金黃色葡萄球菌黃素一樣能夠抵擋游離基的攻擊外,其本身帶有負極的性質更能與兩隻帶有正極的常用抗真菌素(amphotericin B 及 caspofungin)結合,大大削弱藥物傷害真菌的能力。689Please respect copyright.PENANAQOAJ1XVr8M
689Please respect copyright.PENANAxmwz5LFJuh
689Please respect copyright.PENANAHJj7jGnjFg
延伸閱讀:689Please respect copyright.PENANAz5iCqzpFOz
深入淺出–從深海生物中發掘出抗真菌藥物689Please respect copyright.PENANAmsrG0K5B2y
- 分享自 LIHKG 討論區689Please respect copyright.PENANAmLeWZ6mano
https://lih.kg/2296185689Please respect copyright.PENANAnxfKllTz5w
689Please respect copyright.PENANAfSROxIgUB2
689Please respect copyright.PENANA3L86Q1zdA4
如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。689Please respect copyright.PENANAb3FcfzcEkl
689Please respect copyright.PENANA5YOiSpz7Qh
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc689Please respect copyright.PENANAcoSTsO1Nia
689Please respect copyright.PENANAeVSrLvjV6i
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。689Please respect copyright.PENANAThfDTWhb16
689Please respect copyright.PENANA9PkJSPZuwJ
Link:689Please respect copyright.PENANAXpG13MrDyv
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio689Please respect copyright.PENANA9g2uxOzGvh
689Please respect copyright.PENANAqQVIZLHKQC
689Please respect copyright.PENANAgdCTayBbYS
除非Facebook及IG重開侵侵的account,否則我的IG將不會再作更新,只會寄居本土LIHKG及Penana。689Please respect copyright.PENANAovTUNv0b5t
689Please respect copyright.PENANAakwNDWeiny
Ref1:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2743764/689Please respect copyright.PENANAA1nwv2Cvc4