減低食慾從而減少進食，某程度上亦可看成為對抗肥胖或癡肥的其中一道方法。1037Please respect copyright.ＰＥＮＡＮＡ8R6FGkxcyJ
1037Please respect copyright.ＰＥＮＡＮＡeuQOAmxQUq
1037Please respect copyright.ＰＥＮＡＮＡggpSTuKzEA
一直亦有不少研究試圖探討荷爾蒙與食慾的關係，1037Please respect copyright.ＰＥＮＡＮＡQTotexEUp8
其中之一的目標就是設計出一款能壓抑食慾的藥物，輔助癡肥或糖尿病人的治療。1037Please respect copyright.ＰＥＮＡＮＡr0mHC8dY44
1037Please respect copyright.ＰＥＮＡＮＡQAnlihTczj
1037Please respect copyright.ＰＥＮＡＮＡ1oDaoOTadN
(圖2)我們的食慾由下丘腦(Hypothalamus)所控制。1037Please respect copyright.ＰＥＮＡＮＡSBkCa6OsrW
1037Please respect copyright.ＰＥＮＡＮＡtu7cnHhA3T
1037Please respect copyright.ＰＥＮＡＮＡh1tOtgEUaM
以非常簡化的角度來說，在飽肚狀態下，含有MC4R蛋白質的神經細胞便會受到刺激，我們的食慾亦會隨之受到壓抑。1037Please respect copyright.ＰＥＮＡＮＡ1uZ3R7Lfhg
1037Please respect copyright.ＰＥＮＡＮＡHb6KiLBxTg
相反，在飢餓狀態下，含有MC4R蛋白質的神經細胞便會受到壓抑，我們的食慾亦會隨之而來。1037Please respect copyright.ＰＥＮＡＮＡFdJTY46aZa
1037Please respect copyright.ＰＥＮＡＮＡl6S8fTXojU
老鼠缺乏MC4R蛋白質的話，體重亦會明顯上升。1037Please respect copyright.ＰＥＮＡＮＡuhhCxqC9OD
而MC4R的蛋白質因基因變異而導致部份功能的喪失，亦能在不少癡肥人士身上記錄得到。1037Please respect copyright.ＰＥＮＡＮＡrQLWAhdJnM
1037Please respect copyright.ＰＥＮＡＮＡej3Zz3LVis
1037Please respect copyright.ＰＥＮＡＮＡInGi4FugKu
(圖3)刺激MC4R，便能減低食慾，減低食慾，便能減低進食量，有助對抗癡肥。1037Please respect copyright.ＰＥＮＡＮＡWUByoTRveJ
1037Please respect copyright.ＰＥＮＡＮＡTVwkIqba2o
1037Please respect copyright.ＰＥＮＡＮＡrQfDJd8ZRg
第一代刺激MC4R的藥物基於其附帶的血壓上升副作用，不得不終止研究及停止發展。1037Please respect copyright.ＰＥＮＡＮＡZQL5NIcv3b
1037Please respect copyright.ＰＥＮＡＮＡ7ycJgac8AN
而好消息的是，最近(2020年11月)FDA批准了新一代刺激MC4R的藥物Setmelanotide，並沒有血壓上升的副作用，在符合對應的條件下可用作體重管理之用。1037Please respect copyright.ＰＥＮＡＮＡnF8pnJhoUq
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如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。1037Please respect copyright.ＰＥＮＡＮＡQYhxjMG7oh
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Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc1037Please respect copyright.ＰＥＮＡＮＡ9gdCC750O2
1037Please respect copyright.ＰＥＮＡＮＡGF9zV7R7ZF
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。1037Please respect copyright.ＰＥＮＡＮＡYphPtc4pBb
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Link:1037Please respect copyright.ＰＥＮＡＮＡrVwPp93IyJ
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio1037Please respect copyright.ＰＥＮＡＮＡUVQCjR0xkE
1037Please respect copyright.ＰＥＮＡＮＡSsff821Ufn
1037Please respect copyright.ＰＥＮＡＮＡ9a28n7umBa
除非Facebook及IG重開侵侵的account，否則我的IG將不會再作更新，只會寄居本土LIHKG及Penana。1037Please respect copyright.ＰＥＮＡＮＡjmjhVTa0Cy
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Ref1:https://pubmed.ncbi.nlm.nih.gov/33137293/1037Please respect copyright.ＰＥＮＡＮＡ4FSK4jm5ob
Ref2:https://www.sciencedirect.com/science/article/pii/S22128778210004661037Please respect copyright.ＰＥＮＡＮＡeNw3vikaYK
Ref3:https://pubmed.ncbi.nlm.nih.gov/9019399/1037Please respect copyright.ＰＥＮＡＮＡNH20YDThn1
Ref4:https://pubmed.ncbi.nlm.nih.gov/12646665/1037Please respect copyright.ＰＥＮＡＮＡSliEKvsT7b
Ref5:https://pubmed.ncbi.nlm.nih.gov/18454148/1037Please respect copyright.ＰＥＮＡＮＡKe0KmrafA8
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