減低食慾從而減少進食，某程度上亦可看成為對抗肥胖或癡肥的其中一道方法。1104Please respect copyright.ＰＥＮＡＮＡ8bqmjWoTUI
1104Please respect copyright.ＰＥＮＡＮＡlMy4MpS1FG
1104Please respect copyright.ＰＥＮＡＮＡjwFwNiGatu
一直亦有不少研究試圖探討荷爾蒙與食慾的關係，1104Please respect copyright.ＰＥＮＡＮＡlxTqnYhIcx
其中之一的目標就是設計出一款能壓抑食慾的藥物，輔助癡肥或糖尿病人的治療。1104Please respect copyright.ＰＥＮＡＮＡ372oYj3O1J
1104Please respect copyright.ＰＥＮＡＮＡK0r1Sn0jSz
1104Please respect copyright.ＰＥＮＡＮＡuub6X3wuhM
(圖2)我們的食慾由下丘腦(Hypothalamus)所控制。1104Please respect copyright.ＰＥＮＡＮＡVw9qVbDECG
1104Please respect copyright.ＰＥＮＡＮＡUJemOdn4kL
1104Please respect copyright.ＰＥＮＡＮＡD38JQRUxr4
以非常簡化的角度來說，在飽肚狀態下，含有MC4R蛋白質的神經細胞便會受到刺激，我們的食慾亦會隨之受到壓抑。1104Please respect copyright.ＰＥＮＡＮＡ0KXDlK856J
1104Please respect copyright.ＰＥＮＡＮＡEfPVCnRI5j
相反，在飢餓狀態下，含有MC4R蛋白質的神經細胞便會受到壓抑，我們的食慾亦會隨之而來。1104Please respect copyright.ＰＥＮＡＮＡgKmT0UkDoo
1104Please respect copyright.ＰＥＮＡＮＡwLgvoDKlWn
老鼠缺乏MC4R蛋白質的話，體重亦會明顯上升。1104Please respect copyright.ＰＥＮＡＮＡtYJWhBK5IM
而MC4R的蛋白質因基因變異而導致部份功能的喪失，亦能在不少癡肥人士身上記錄得到。1104Please respect copyright.ＰＥＮＡＮＡN5bhaPXbMy
1104Please respect copyright.ＰＥＮＡＮＡ2cpuyu2P99
1104Please respect copyright.ＰＥＮＡＮＡ6oCbCedbhA
(圖3)刺激MC4R，便能減低食慾，減低食慾，便能減低進食量，有助對抗癡肥。1104Please respect copyright.ＰＥＮＡＮＡFkwVe1Tka4
1104Please respect copyright.ＰＥＮＡＮＡPrnBSn34N5
1104Please respect copyright.ＰＥＮＡＮＡiU3lgWRKIb
第一代刺激MC4R的藥物基於其附帶的血壓上升副作用，不得不終止研究及停止發展。1104Please respect copyright.ＰＥＮＡＮＡhefV92JE0H
1104Please respect copyright.ＰＥＮＡＮＡOcDjppDmhd
而好消息的是，最近(2020年11月)FDA批准了新一代刺激MC4R的藥物Setmelanotide，並沒有血壓上升的副作用，在符合對應的條件下可用作體重管理之用。1104Please respect copyright.ＰＥＮＡＮＡqCFrgUFwak
1104Please respect copyright.ＰＥＮＡＮＡhK4e3N9glC
1104Please respect copyright.ＰＥＮＡＮＡOyojT1FAxz
如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。1104Please respect copyright.ＰＥＮＡＮＡPuhYx872x4
1104Please respect copyright.ＰＥＮＡＮＡsSJbbJh1n4
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc1104Please respect copyright.ＰＥＮＡＮＡv6bGlDC3vE
1104Please respect copyright.ＰＥＮＡＮＡmt61HveHWR
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。1104Please respect copyright.ＰＥＮＡＮＡmHILBp0vkQ
1104Please respect copyright.ＰＥＮＡＮＡn3lY4ItUIA
Link:1104Please respect copyright.ＰＥＮＡＮＡLh2NxSOsyD
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio1104Please respect copyright.ＰＥＮＡＮＡabsyHOqrp6
1104Please respect copyright.ＰＥＮＡＮＡKE08iW0Bk5
1104Please respect copyright.ＰＥＮＡＮＡ0P3XHPSJi8
除非Facebook及IG重開侵侵的account，否則我的IG將不會再作更新，只會寄居本土LIHKG及Penana。1104Please respect copyright.ＰＥＮＡＮＡnqZiLaObz2
1104Please respect copyright.ＰＥＮＡＮＡvlBALBy5yQ
Ref1:https://pubmed.ncbi.nlm.nih.gov/33137293/1104Please respect copyright.ＰＥＮＡＮＡN2BgIGsx2i
Ref2:https://www.sciencedirect.com/science/article/pii/S22128778210004661104Please respect copyright.ＰＥＮＡＮＡa0UY2bdqdH
Ref3:https://pubmed.ncbi.nlm.nih.gov/9019399/1104Please respect copyright.ＰＥＮＡＮＡGoQCtbH2W8
Ref4:https://pubmed.ncbi.nlm.nih.gov/12646665/1104Please respect copyright.ＰＥＮＡＮＡ6AliczZjKQ
Ref5:https://pubmed.ncbi.nlm.nih.gov/18454148/1104Please respect copyright.ＰＥＮＡＮＡtNETuuY8TG
Penana
search
Loginarrow_drop_down
Registerarrow_drop_down
