其中一道腫瘤形成的理論，就是經過無數基因異變的洗滌下，有助癌細胞生長的基因(Oncogene)不斷產生出來對它們有利的蛋白質，而負責抑制癌細胞生長的基因(Tumor Suppressor)則失去功用，沒能產生出制衝它們的蛋白質。625Please respect copyright.ＰＥＮＡＮＡ2RTrlLjUVY
625Please respect copyright.ＰＥＮＡＮＡB962VDN07g
625Please respect copyright.ＰＥＮＡＮＡw3p3n0595s
在製藥角度來看，對付Oncogene常理上較為合理，畢竟抑制事物比起激發事物會來得更為容易。625Please respect copyright.ＰＥＮＡＮＡBhcPTNPoqJ
625Please respect copyright.ＰＥＮＡＮＡ4rlnT1z1Ku
（圖2）P53蛋白質是其中一隻Tumor Suppressor，它最常見的變異版本就R175H，意思是它的第175個氨基酸發生了異變。625Please respect copyright.ＰＥＮＡＮＡZckjRqWJ4N
625Please respect copyright.ＰＥＮＡＮＡsU2k9sz0iB
625Please respect copyright.ＰＥＮＡＮＡbAyXAtzQQm
P53蛋白質延伸閱讀:625Please respect copyright.ＰＥＮＡＮＡIB41AH7UBs
分半鐘科學–缺氧對癌細胞的好處625Please respect copyright.ＰＥＮＡＮＡNNliqTgrUz
https://lih.kg/2420256625Please respect copyright.ＰＥＮＡＮＡe2yHnR4878
625Please respect copyright.ＰＥＮＡＮＡ2TkCHrfjik
雖然P53蛋白質主要是位於細胞內部，但當中會有一小節的蛋白質會表達在細胞表面上，名為新生抗原(Neoantigen)，數量極為稀少，可以少至1顆細胞只有10塊表達在其表面上。625Please respect copyright.ＰＥＮＡＮＡWqidGeUkcV
625Please respect copyright.ＰＥＮＡＮＡ6D6yfCTRWD
現時有科學家開始從針對Tumor Suppressor入手，製作出「雙面人」抗體(Bispecific antibodies)，一面辨認癌細胞的新生抗原，另一面則會辨認免疫細胞T cell，目的就是希望透過雙面人抗體拉近免疫細胞與癌細胞的距離，促使免疫細胞更有效率地對癌細胞進行皇天擊殺。625Please respect copyright.ＰＥＮＡＮＡiOZNrv3VHy
625Please respect copyright.ＰＥＮＡＮＡ4xpLn9cuiF
（圖3）對老鼠注射平均表面每顆平均只有2塊變種版本新生抗原的癌細胞，七日後可從螢光技術見得到腫瘤有著增大的趨勢。625Please respect copyright.ＰＥＮＡＮＡZfbTnp0u7x
625Please respect copyright.ＰＥＮＡＮＡl71XhQ5XFS
625Please respect copyright.ＰＥＮＡＮＡZkQJtlm5BH
而注射能辨認P53蛋白質R175H變種的雙面人抗體後，腫瘤體積顯著有所減少。625Please respect copyright.ＰＥＮＡＮＡlW2BlPK2Fr
625Please respect copyright.ＰＥＮＡＮＡwKjywXOUzA
這技術的好處是能夠針對殺滅擁有特定變異基因的癌細胞，但基於每顆癌細胞的變異位置及程度均有所不同，要活用這技術的話便必須要獲取該病人的癌細胞基因變異狀況。625Please respect copyright.ＰＥＮＡＮＡSQ7lqYvzIO
625Please respect copyright.ＰＥＮＡＮＡNDUmv3ITbk
螢光技術延伸閱讀:625Please respect copyright.ＰＥＮＡＮＡ3kEeG3XSRH
三十秒科學–透視癌細胞625Please respect copyright.ＰＥＮＡＮＡ7DdUKNmHE4
https://lih.kg/2408323625Please respect copyright.ＰＥＮＡＮＡ09aQkPco8O
625Please respect copyright.ＰＥＮＡＮＡaBXSLwcDtx
如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。625Please respect copyright.ＰＥＮＡＮＡVrwLsvHtD7
625Please respect copyright.ＰＥＮＡＮＡ67Z1L5Q1iK
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc625Please respect copyright.ＰＥＮＡＮＡWWdxxB4Ohd
625Please respect copyright.ＰＥＮＡＮＡnT8TuaFG7k
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。625Please respect copyright.ＰＥＮＡＮＡcIIwx67AG2
625Please respect copyright.ＰＥＮＡＮＡTBbpedkq7Q
Link:625Please respect copyright.ＰＥＮＡＮＡR02vPYukoY
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio625Please respect copyright.ＰＥＮＡＮＡyM68Go4tqc
625Please respect copyright.ＰＥＮＡＮＡlSnzaYCBve
625Please respect copyright.ＰＥＮＡＮＡxHuFykRm4W
除非Facebook及IG重開侵侵的account，否則我的IG將不會再作更新，只會寄居本土LIHKG及Penana。625Please respect copyright.ＰＥＮＡＮＡU0liOmaNGZ
625Please respect copyright.ＰＥＮＡＮＡEtjgz1zdGx
Ref1:https://science.sciencemag.org/content/early/2021/02/26/science.abc8697625Please respect copyright.ＰＥＮＡＮＡpqRtZSRERS
Penana
search
Loginarrow_drop_down
Registerarrow_drop_down
