癌細胞的新陳代謝與普通細胞有著顯著的分別,原因是癌細胞需要截然不同的新陳代謝來滿足生長的需要。591Please respect copyright.PENANArFIE4xUsmK591Please respect copyright.PENANAahPfQjNZqr
但是,當癌細胞從原有位置轉移到另一位置後,其新陳代謝有會否有所轉變呢?591Please respect copyright.PENANAG4QXdHZkPa
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(圖2)mTORC1是其中一隻掌管細胞生長的蛋白質,而有研究(Ref1)指出,從乳癌轉移到肺部的癌細胞,其mTORC1所帶來的效果更為強大,能令癌細胞生長得更快。591Please respect copyright.PENANAJpw1a48Hzb591Please respect copyright.PENANAo6xDDuh4p1
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(圖3)科學家發現,肺部含有充足的Pyruvate代謝物,而利用藥物阻擋「乳癌轉移過來的肺癌」吸收Pyruvate的話,便能減低mTORC1的功效。591Please respect copyright.PENANA3IGMpAKqVZ591Please respect copyright.PENANAD2fGwabKWV
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但奇怪的是,用藥物阻擋原發腫瘤乳癌吸收Pyruvate的話,mTORC1的功效並不會有所減低,腫瘤生長的速度並無任何特別變化。591Please respect copyright.PENANAScvAGejgG9
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這顯示出,癌細胞從原有地方轉移到另一位置後,其新陳代謝亦有著顯著的變化。591Please respect copyright.PENANAkPrKxOl3VY
這有可能是因為第二處位置的生長環境有所不同,故此癌細胞需要調節其新陳代謝來適應新環境。591Please respect copyright.PENANAK5RLMz1pWp
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在乳癌轉移到肺部的癌細胞,我們可透過針對Pyruvate的吸收來減慢他們的生長,但這是否只適用於從其他位置轉移到肺部的癌細胞,以及乳癌轉移到其他位置的癌細胞,那還需要進一步的研究確實。591Please respect copyright.PENANAFoNLmX1fLq
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Ref1:https://www.sciencedirect.com/science/article/pii/S1097276520308273591Please respect copyright.PENANAYK8pObbEJZ