癌細胞從原處走到另一地方(轉移,Metastasis),均需透過血液或淋巴系統作交通渠道。633Please respect copyright.PENANA7S9qzfhFOy633Please respect copyright.PENANAZK3trJizJT
633Please respect copyright.PENANAHbwv11pU1X
有不少癌細胞轉移到另一器官後會呈「休養」狀態,不迅速繁殖,而是長期潛伏在另一器官內。633Please respect copyright.PENANANVQ85k25qi
633Please respect copyright.PENANArc7l3a0gOT
因此就算沒能檢測得到循環腫瘤細胞的存在,也不百分百等於未來不會出現癌細胞轉移事件。633Please respect copyright.PENANAvz7iPAkXEo
633Please respect copyright.PENANAgwSv2aY1Kt
633Please respect copyright.PENANA2bHDZHl4qI
(圖2)科學家分別把人類及老鼠的癌細胞注入到老鼠模型作研究,發現癌細胞發生轉移的機率是與目的地所含的NK cell數量有關係。633Please respect copyright.PENANAduoT0WRmdD633Please respect copyright.PENANAj3MI8g10tl
633Please respect copyright.PENANAko4eZibv0j
目的地所含的NK cell越多,該地方出現癌細胞轉移的機率亦會越低。633Please respect copyright.PENANAeW1TFA68F8
633Please respect copyright.PENANAi5fT9gtBO2
之所以會出現這情況,除了是NK cell殺死癌細胞這可能性之外,科學家發現NK cell會釋放interferon-γ (IFN-γ)的物質,誘使癌細胞進入休養狀態,不進行自我繁殖。633Please respect copyright.PENANA1Z3z2bGxEZ
633Please respect copyright.PENANA7zUz2ZRfjk
633Please respect copyright.PENANAgb51i7LShs
(圖3)奈何,至少在肝臟裡頭,一種名為Hepatic stellate cells會釋出CXCL12物質,CXCL12會阻礙NK cell的生長速度。633Please respect copyright.PENANAyU4JGI8vfp633Please respect copyright.PENANAI1UM2guPIp
633Please respect copyright.PENANAkfvjD8Z16N
633Please respect copyright.PENANAd7eHgZvv6s
久而久之,便再也沒有足夠的NK cell抑制癌細胞的生長,而當潛伏在另一器官的癌細胞快速繁殖之時,這亦是轉移(Metastasis)被鑑定發生之時。633Please respect copyright.PENANAzm3mn7OFdi
633Please respect copyright.PENANADO37IxhvYs
633Please respect copyright.PENANAqErrr5N4qQ
對此,研發藥物或療程確保NK cell長期處於足夠水平,或許是一道避免癌細胞發生轉移的大方向。633Please respect copyright.PENANA2P8fu1RNeJ
633Please respect copyright.PENANAilmDI3dX8h
如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。633Please respect copyright.PENANAP4P2DcOlNQ
633Please respect copyright.PENANAfgkIqfRk1U
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc633Please respect copyright.PENANATGB3Pwja8I
633Please respect copyright.PENANAia4vf0XSbu
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。633Please respect copyright.PENANAVmOzgUIczP
633Please respect copyright.PENANAEIXesgLT0j
Link:633Please respect copyright.PENANAg9RlYzid8b
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio633Please respect copyright.PENANACEFcvDKOEJ
633Please respect copyright.PENANAuUnAXfr6jW
633Please respect copyright.PENANAmRTpzdlZrB
除非Facebook及IG重開侵侵的account,否則我的IG將不會再作更新,只會寄居本土LIHKG及Penana。633Please respect copyright.PENANA7mdtNJZxNz
633Please respect copyright.PENANAth3YlSmPZs
Ref1:https://www.nature.com/articles/s41586-021-03614-z633Please respect copyright.PENANA1q1WrGdHji