癌細胞從原處走到另一地方(轉移,Metastasis),均需透過血液或淋巴系統作交通渠道。679Please respect copyright.PENANAIwVDnR3vZ0679Please respect copyright.PENANAfRZkRuWwxb
679Please respect copyright.PENANAfuGEz5awhM
有不少癌細胞轉移到另一器官後會呈「休養」狀態,不迅速繁殖,而是長期潛伏在另一器官內。679Please respect copyright.PENANAFsqyBnc1Ts
679Please respect copyright.PENANAiIEMS9ZBya
因此就算沒能檢測得到循環腫瘤細胞的存在,也不百分百等於未來不會出現癌細胞轉移事件。679Please respect copyright.PENANANvdYrYGBBY
679Please respect copyright.PENANAE3xVj28fWI
679Please respect copyright.PENANAgjpObFkuOP
(圖2)科學家分別把人類及老鼠的癌細胞注入到老鼠模型作研究,發現癌細胞發生轉移的機率是與目的地所含的NK cell數量有關係。679Please respect copyright.PENANAgWMZ2i2cbT679Please respect copyright.PENANAajbdRtaNq4
679Please respect copyright.PENANA8KxO27IUSe
目的地所含的NK cell越多,該地方出現癌細胞轉移的機率亦會越低。679Please respect copyright.PENANAapkBFawGFg
679Please respect copyright.PENANAeocRmzSfGX
之所以會出現這情況,除了是NK cell殺死癌細胞這可能性之外,科學家發現NK cell會釋放interferon-γ (IFN-γ)的物質,誘使癌細胞進入休養狀態,不進行自我繁殖。679Please respect copyright.PENANABiYyyuOca5
679Please respect copyright.PENANAs0HHRewBQU
679Please respect copyright.PENANAgDLaQih2a7
(圖3)奈何,至少在肝臟裡頭,一種名為Hepatic stellate cells會釋出CXCL12物質,CXCL12會阻礙NK cell的生長速度。679Please respect copyright.PENANAXCnXsqnHpx679Please respect copyright.PENANAm4kxC5qv8l
679Please respect copyright.PENANAjl5T2cydF1
679Please respect copyright.PENANAvI9bmFnILu
久而久之,便再也沒有足夠的NK cell抑制癌細胞的生長,而當潛伏在另一器官的癌細胞快速繁殖之時,這亦是轉移(Metastasis)被鑑定發生之時。679Please respect copyright.PENANAGMtBI12eec
679Please respect copyright.PENANAHOgUtvWFpZ
679Please respect copyright.PENANA8iW4pNRZif
對此,研發藥物或療程確保NK cell長期處於足夠水平,或許是一道避免癌細胞發生轉移的大方向。679Please respect copyright.PENANAxPYlgTEc6w
679Please respect copyright.PENANABgeVwH6oEI
如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。679Please respect copyright.PENANA5SWo5LlXIV
679Please respect copyright.PENANAwTKpEs1G0l
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc679Please respect copyright.PENANAaFOvch0UCb
679Please respect copyright.PENANAA4c1KiyPU0
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。679Please respect copyright.PENANAbQWvoIu9rJ
679Please respect copyright.PENANAArK5zZSgw7
Link:679Please respect copyright.PENANAf50JPrleuQ
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio679Please respect copyright.PENANAbHEiSZmw4a
679Please respect copyright.PENANAiXWoZP1Mhk
679Please respect copyright.PENANA0W6L4KUsT0
除非Facebook及IG重開侵侵的account,否則我的IG將不會再作更新,只會寄居本土LIHKG及Penana。679Please respect copyright.PENANA2FijxtHwZY
679Please respect copyright.PENANAshkIff35CE
Ref1:https://www.nature.com/articles/s41586-021-03614-z679Please respect copyright.PENANAiioZJkCl98