癌細胞逃避免疫細胞追殺的手段何其之多,除了較早前提及的PD1/PD1L手段之外,他們亦會用上民建聯蛇齋餅糉的手段應對免疫細胞。280Please respect copyright.PENANAj7s30AuqRD280Please respect copyright.PENANArSDHoUq2qm
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PD1/PD1L手段:https://lih.kg/gzGnLS280Please respect copyright.PENANAKqfXQwpPoG
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(圖2)癌細胞(尤其是腦癌)會表達大量的TDO蛋白酶,TDO蛋白酶會將從外來吸取的氨基酸Tryptophan代謝成為Kynureine;280Please respect copyright.PENANAcPyfPW1a4I
整個代謝過程是在癌細胞的內部發生。280Please respect copyright.PENANAWfhB7tGbL5280Please respect copyright.PENANA49htoQmx3j
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(圖3)癌細胞可以自用Kynurenine來觸發AhR蛋白質,輔助自己的生長。280Please respect copyright.PENANAzEUwZgW6PI
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同時間,癌細胞亦可將Kynurenine排出四周,而當周遭的免疫細胞吸取Kynurenine後,他們殲滅癌細胞的能力便會下降。280Please respect copyright.PENANA8YbpzYNGHF
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亦即是說,當免疫細胞獲取癌細胞所提供的蛇齋餅糉(Kynurenine)後,隨之便會被成功收買,不再侵襲癌細胞。280Please respect copyright.PENANALOFXgLuBXr
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(圖4)除Kynurenine外,二噁英亦能觸發AhR蛋白質,為癌細胞締造一道美好的生存環境。280Please respect copyright.PENANAVrSJUl88yQ
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現今有不少癌症藥物正試圖阻隔AhR蛋白質的觸發來消滅癌症,但亦有證據指出過度阻隔AhR蛋白質有機會反而助長癌細胞的生長,以及引發不良的過敏炎症。280Please respect copyright.PENANAVA5jHcA0WD
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除研發阻隔AhR蛋白質藥物外,亦有一道方向是研發藥物減低周遭的Kynurenine濃度,減低癌細胞弱化周遭免疫細胞的能力。280Please respect copyright.PENANAUrvKFiEROa
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若然成功,或許能配合現有的免疫治療PD1方法加強效果,消滅癌症。280Please respect copyright.PENANACxTKQ0j7RA
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如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。280Please respect copyright.PENANAvLd4WR19qG
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同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。280Please respect copyright.PENANACFGNIeISxY
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Link:280Please respect copyright.PENANAr0gFOK5DKl
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio280Please respect copyright.PENANAdKlBiJBFcH
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基於WhatsApp/Facebook等問題,IG將不會再作更新,只會寄居本土LIHKG及Penana。280Please respect copyright.PENANA4TwCy29kCx
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Ref1:https://www.nature.com/articles/nature10491280Please respect copyright.PENANAGg5N7b8sGY
Ref2:https://www.sciencedirect.com/science/article/pii/S0165614717302249280Please respect copyright.PENANAgV8hWdDPpP