不少的癌症病人均會出現體重及BMI急速下降的情況,肌肉會出現萎縮,脂肪組織亦有機會有所消耗,這現象稱之為Cancer-associated cachexia(CAC)。351Please respect copyright.PENANAIQvTDx9FLI351Please respect copyright.PENANAwxWFfjP8xm
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與厭食症不同的是,體重的流失並沒能依靠增加進食來進行完全填補。351Please respect copyright.PENANAVp69OaHFUW
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(圖2)CAC的形成,是腫瘤與身體多種器官互動後所得出的結果,箇中涉及新陳代謝及荷爾蒙的轉變。351Please respect copyright.PENANAV7rJOBgGM6351Please respect copyright.PENANAjDOkgntrYy
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(圖3)從圖中所見,老鼠出現腫瘤約21日後,腿部肌肉出現萎縮,與人類的CAC現象吻合。351Please respect copyright.PENANA1pWmNkLd0e351Please respect copyright.PENANAz3P6DuCNPI
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PTHrP是一種某類型的腫瘤釋放到血管的蛋白質,而往老鼠注射PTHrP蛋白質抗體的話,肌肉的萎縮程度亦有所緩和。351Please respect copyright.PENANApMPxigWmPr
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只可是,往健康老鼠注射PTHrP蛋白質的話,肌肉並不會貿然萎縮,而往出現腫瘤的老鼠注射PTHrP蛋白質的話,肌肉萎縮的程度反會更加劇烈。351Please respect copyright.PENANAcnpYfD8UcQ
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這亦證明,PTHrP蛋白質只是導致癌症時候肌肉萎縮的其中一道組件,還需要癌細胞另外的付出才可達成。351Please respect copyright.PENANAVwOBCOjZr6
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癌症所帶來的CAC現象,會導致藥物對其他正常器官出現更強烈的副作用及毒性。這變相需要降低用藥的劑量作出配合,因而減低了滅癌的效率。351Please respect copyright.PENANAYId7TYAtvB
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因此,現今科學家亦在努力嘗試找出CAC的整套機制,務求找出有效的醫學方法制止CAC的產生。351Please respect copyright.PENANA7aMAGgO6kG
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同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。351Please respect copyright.PENANA62yKrD7vj9
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https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio351Please respect copyright.PENANA8zNat0w9dS
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基於WhatsApp/Facebook等問題,IG將不會再作更新,只會寄居本土LIHKG及Penana。351Please respect copyright.PENANAlgicfyWHAs
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Ref1:https://www.nature.com/articles/nature13528351Please respect copyright.PENANAceCduYfM4v