歸立治理武肺的手段,現時可分為疫苗、人造抗體、藥物以及各式化合物四大手段。469Please respect copyright.PENANAq8y0OLzjnZ
469Please respect copyright.PENANAkQGhANP6Nr
疫苗具「長遠」預防作用,但不能醫治已受感染的病人,而且年長人士亦有可能基於免疫系統已甚為衰退關係,沒能被疫苗誘導身體製造充夠份量的抗體。469Please respect copyright.PENANA0A6PqXq7NO
469Please respect copyright.PENANARdPSxIkMOd
人造抗體具有短期的預防及醫治效果,不受年齡界別所限,但預防的期限顯然會比疫苗為短。469Please respect copyright.PENANAry1WbYoEP9
469Please respect copyright.PENANAscqdMWkJ7L
藥物「理論上」沒有預防效用,但帶有醫治效果,暫時具認可能醫治武肺的藥物為Remdesivir (瑞德西韋)及Dexamethasone (地塞米松–超繽紛怪異的名字)。469Please respect copyright.PENANAZrKFnge42t
469Please respect copyright.PENANAwQdp6yjhno
各式化合物的包括Solube ACE2及AngII等等,某程度上亦可界定為藥物。469Please respect copyright.PENANArIJVf2pTws
469Please respect copyright.PENANA44Z55bO7ya
469Please respect copyright.PENANA3DomDxdCUv
上一個Post粗略講解過人造抗體的最新發展,今個Post將會講解藥物發展的最新狀況,尤其在老藥新用(Drug Repurposing)方面之上。469Please respect copyright.PENANAFPQjgW0sgL
469Please respect copyright.PENANATRRC3kLIUa
抵抗武肺的黑馬–人造抗體469Please respect copyright.PENANAkbUe90laWT
- 分享自 LIHKG 討論區469Please respect copyright.PENANAlWgzXPjujc
https://lih.kg/2141521469Please respect copyright.PENANAVSiS3b5J2D
469Please respect copyright.PENANAj4pQGiJ3Zq
老藥新用並唔係新穎概念,最為與人類生活相關的其中一隻,就係生髮洗頭水裡的Minoxidil。本來Minoxidil的主要用途為抗高血壓用,但輾轉之下發現竟然具有促進頭髮生長的效果,所以亦變成為增髮藥物之一。469Please respect copyright.PENANAfitlPazPKC
469Please respect copyright.PENANANnSNcTBYJd
事實上,用來醫治武肺的Remdesivir (瑞德西韋)原本是Gilead Science針對伊波拉病毒(Ebola)所研發的藥物,但結果並不理想。469Please respect copyright.PENANANeho5xXc54
後來Remdesivir被發現能夠有效抑制中東呼吸綜合征冠狀病毒(MERS)在在細胞上的繁殖,科學家便因而嘗試利用它來對抗武肺,發現同樣能抑壓武肺在細胞裡的繁殖。469Please respect copyright.PENANAZwsIaIfKPw
469Please respect copyright.PENANA7ld4Gdmbtp
最近袁教授同美國嗰邊合作發表一份《Nature》文章,在約12000藥物中,搵到21隻能夠增強Remdesivir阻礙武肺生長的效果。(Ref1)469Please respect copyright.PENANA1s1u1j2kzL
換句話說,若果將21隻藥物內其中一隻與Remdesivir一同使用的話,就可以降低Remdesivir劑量濃度的同時亦能達到治理效果,變相能夠減低Remdesivir產生副作用的機會。469Please respect copyright.PENANAI3o9mnzS1j
469Please respect copyright.PENANAbPFz7lTM7w
暫時來說,所有結果均來自實驗室細胞研究。469Please respect copyright.PENANAHQvhJhoWRX
如果兩隻藥一齊運用的話,會否真的是對人體產生正面作用,又或者會產生出新的副作用,仍是未知之數。469Please respect copyright.PENANAcM3LujJcCt
469Please respect copyright.PENANAo2wQl6ronF
不過現時當務之急是解決武肺,基本上所有事物都會「開捷徑」同步進行。而就在8月5日,一批科學家發批學術文章(Ref2)利用AI技術設立一套名為Synthia的軟件,更成功為11隻相信能醫治武肺的藥物找出一套更便宜更有效率的合成方法,方便藥廠商可以用更低的成本大量製造藥物(雖然廠商未必會因而調低價格,反之.......)。469Please respect copyright.PENANAXAofAjFJcc
469Please respect copyright.PENANA7v1o2Ka9VD
只可惜的是,就算套用了他們的AI軟件,依然沒能找出一種比現時Gilead Science釀製Remdesivir的更好方法。469Please respect copyright.PENANA8fEL6MmXm4
469Please respect copyright.PENANAsFlZ3o9og9
Ref1:https://www.nature.com/articles/s41586-020-2577-1469Please respect copyright.PENANAuNbU6LhLUH
Ref2:https://chemrxiv.org/articles/preprint/Reinforcing_the_Supply_Chain_of_COVID-19_Therapeutics_with_Expert-Coded_Retrosynthetic_Software/12765410
143
ns 172.69.7.6da2