近日有急凍雞翼及其他產品被測量出擁有武肺存在,但武肺能否在雞翼或其他食物上大量繁殖呢?741Please respect copyright.PENANAyCoVbxRvDi
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答案是,不可以。741Please respect copyright.PENANABfepi1LRYW
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武肺進行大量繁殖的話,必需要借助活生生的細胞幫忙,而其中先決的一步就是要進入細胞體內。741Please respect copyright.PENANA7YGLwVkgXt
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武肺可否入侵細胞,基本上視乎可唔可以達成下列3個條件。741Please respect copyright.PENANAvs6HktZY4f
(圖1)741Please respect copyright.PENANAWF5ZDERR2n741Please respect copyright.PENANAL5u1KS2H5r
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1. S protein與細胞表面的ACE2觸碰。741Please respect copyright.PENANAd5GVqGgLE6
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2. 細胞表面ACE2與S protein的形狀吻合,亦即是「啱嘴形」。741Please respect copyright.PENANAYGfy2PBLDb
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3. 細胞表面擁有TMPRSS2蛋白質,能夠對S protein進行切割。741Please respect copyright.PENANArNYiYx7P3N
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滿足3大條件後,病毒就有能力能夠入侵細胞。741Please respect copyright.PENANAStLdilIRNb
當然,入侵細胞後還有很多因素決定武肺能否大量繁殖,但急凍雞翼連活生生的細胞也沒有,根本無可能可以大量繁殖。741Please respect copyright.PENANAgPnk7vo6V6
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何謂S protein和ACE2,可到我之前所寫的文章溫故知新。741Please respect copyright.PENANAYbImxLcLEd
https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/issue/9741Please respect copyright.PENANAJF2wi3tWri
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(圖2)741Please respect copyright.PENANAWhNdebSv1v
第二點所謂的「啱嘴型」,所指的就是ACE2的形狀能否與武肺的S protein形狀吻合,就好像砌Puzzle一樣,兩者不吻合的話就無法連結一起,勉強亦無幸福。741Please respect copyright.PENANALYu3lCES8Z
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如圖中所見,正因為老鼠ACE2唔啱嘴型,所以武肺無法引致老鼠患上肺炎等病徵,袁教授等人因此亦改用啱嘴型的倉鼠作為武肺的動物實驗模型。741Please respect copyright.PENANA20TfDrpcbc
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(Ref 1)有科學家嘗試將武肺打落豬、雞和鴨身上,最終無法在牠們的任何器官身上找到武肺,而且亦沒有出現任何病徵,因此斷定牠們並不會受到武肺感染。741Please respect copyright.PENANAQDWyuBAvtb741Please respect copyright.PENANAAfKY2BUDIA
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(圖3)741Please respect copyright.PENANAL3ZlYgkYeN
關於第三點,肺(Lung)及腎臟(Kidney)同樣擁有一定數量的ACE2及TMPRSS2(Ref2),因此將會成為武肺的主要針對對象。741Please respect copyright.PENANAPl9PqFUuo5
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而心臟(Heart) 同樣擁有一定數量的ACE2,某程度亦解釋了為何武肺患者康復後會被發現心臟出現異樣。741Please respect copyright.PENANAuRPpKNfmmv
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而男性器官睪丸(Testis),亦是ACE2數量較多的器官(圖中沒有列出),所以,嗯......741Please respect copyright.PENANALEiN7YUlu7
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Ref1:https://science.sciencemag.org/content/368/6494/1016741Please respect copyright.PENANAA2zHHo3sAK
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Ref2:https://www.sciencedirect.com/science/article/pii/S221323172030820X#fig1741Please respect copyright.PENANAPkg2NyvkQu