現今至少有兩間公司的人造抗體(LY/REGN)被緊急認可為武肺的治療方法。329Please respect copyright.PENANArfNwM3hWy6
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但基於這兩種人造抗體需經由血管注射,其間病人需卧床約一小時間,且需求人手密切監察整個過程,實際運行的成本非常高昂,因此未能普及。329Please respect copyright.PENANAS9ljWSnllX
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更甚的是,有數據顯示當人造抗體經血管注射後,能抵達肺部裡頭的數量少至有少(血液抗體含量比肺部抗體含量高出200-500倍有多),且已知當今的武肺病毒變種能有效躲避兩間公司的人造抗體追捕,使至人造抗體的地位日漸式微。329Please respect copyright.PENANALPaGyVgt2k
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(圖2)武肺病毒最主要的作惡地方是肺部,要解決肺部抗體含量過少的問題,其中一道手段就是從鼻腔注射人造抗體,使其能較易直達肺部。329Please respect copyright.PENANA2x7JxKhUYb
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從老鼠模型實驗中,可以見到往鼻腔注射人造抗體後,抗體(紅黃色區域)會聚集在鼻腔(N)及肺部(Lu)裡頭。329Please respect copyright.PENANArD0n3VnUla
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(圖3)至於解決武肺變種的問題,其中一手段就是將五個單一抗體連結成一個個體(五合一),利用「龐大」的身驅阻礙病毒進入細胞。329Please respect copyright.PENANABKUWItnaeh
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在老鼠實驗中,鼻噴式的五合一抗體能有效阻隔英國及巴西變種等病毒,且有著預防及治療武肺的功效,同時亦沒有對老鼠的體重和明顯特徵做成任何影響。329Please respect copyright.PENANArenCeq8J3W
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若能順利通過人體臨床實驗,定必為世界的安定起來重要的作用。329Please respect copyright.PENANADn4Uk5Le4E
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如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。329Please respect copyright.PENANAg9CXHar8oP
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同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。329Please respect copyright.PENANA9vnsJf03IH
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Link:329Please respect copyright.PENANAxX2yRKA4Qz
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio329Please respect copyright.PENANA12zrgWWFLG
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Ref1:https://www.nature.com/articles/s41586-021-03673-2_reference.pdf329Please respect copyright.PENANAIuF7avF0K8