隨著細胞的基因變異一直累積,正常細胞形成癌細胞的機會亦會相應提升。572Please respect copyright.PENANAc1dGjftA7m
572Please respect copyright.PENANAigDmrfnckl
但細胞是否只需要基因變異這一個誘因便能夠轉化為癌細胞呢?572Please respect copyright.PENANAPhmPKBciLg
572Please respect copyright.PENANAZcBBfhOT1X
這一方面還有一定程度的斟酌空間。572Please respect copyright.PENANAntmQ3uKtMt572Please respect copyright.PENANA6Uhn7X4PVc
572Please respect copyright.PENANArXuT8paJpp
舉例來說,NOTCH1基因變異被認定為是推進食道細胞轉化成為癌細胞的其中一個原因。572Please respect copyright.PENANA8lTx9JV3S7
572Please respect copyright.PENANAdAWXGjlRTH
但在長者的健康食道細胞裡頭,約有30-80%的細胞均擁有NOTCH1基因變異,而他們身體並沒有出現及發生食道癌。572Please respect copyright.PENANAh5CQHdxQvT
572Please respect copyright.PENANAMiPrR8wYGT
572Please respect copyright.PENANAMVKxEyiq2Q
(圖2)而在老鼠實驗方面,單憑服用DMBA (引致Hras基因變異)或Croton oil(引致發炎效用,不會促進基因變異)的話,並不會引起癌細胞的出現。572Please respect copyright.PENANA0MeqaPiSNQ
572Please respect copyright.PENANA6pl6xcZY9u
唯獨兩者以先後的方式給予老鼠的話,癌細胞才會有所形成。572Please respect copyright.PENANAJnPZq3QPbj572Please respect copyright.PENANAt42ECiXomF
572Please respect copyright.PENANAS2sKerHAiJ
572Please respect copyright.PENANAgGaL1r8q5Q
這不禁讓科學家開始思考一道問題,是否基因變異再加上某種特定條件,就可以促進癌細胞形成呢?572Please respect copyright.PENANADKlfpG2Mfr
572Please respect copyright.PENANAYgQWKqFqdh
(圖3)為解答這個問題,英國開始了名為Mutographs的計劃,572Please respect copyright.PENANAVygsqspOd9572Please respect copyright.PENANAdzUA4lxloo
572Please respect copyright.PENANA4II0vBCiKr
集5大洲超過5000個病人的癌細胞基因圖譜(主要集中在食道、大腸、腎臟及胰臟癌),572Please respect copyright.PENANABO2NuwgjoY
572Please respect copyright.PENANAdPp9MC8Bzq
同時比對病人的日常習慣(食用習慣、酒精飲用、熱飲喜好等等),572Please respect copyright.PENANAW3FmisCTRD
572Please respect copyright.PENANARBLcu4qpsM
其中一個目標就是想找出哪一種特殊條件配上某一個基因變異會特別容易促進癌細胞的形成。572Please respect copyright.PENANA3kbWnzgolt
572Please respect copyright.PENANAyd6uhgjssA
若然能得出確切的結果並附上內裡的細胞機制支持的話,這將會為預防癌症形成的領域作出重大的貢獻。572Please respect copyright.PENANA5gRqSmLfic
572Please respect copyright.PENANADI491t9GsZ
以上的資料均取自Ref1。572Please respect copyright.PENANAIvwHS2FaFb
572Please respect copyright.PENANA8rwDlpovjH
572Please respect copyright.PENANAXCpvHBm66j
如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。572Please respect copyright.PENANAvPkibYshCI
572Please respect copyright.PENANAQlAibkemUz
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc572Please respect copyright.PENANAeI41mmzr3c
572Please respect copyright.PENANAxeHjkaP1h9
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。572Please respect copyright.PENANAogkePZJLt7
572Please respect copyright.PENANA1wmjCHRGMv
Link:572Please respect copyright.PENANAVQJxxP6oFz
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio572Please respect copyright.PENANA6accyQyVdt
572Please respect copyright.PENANAI10J3Mldyj
572Please respect copyright.PENANAczz4LT97ws
有興趣接收科學資訊的話,歡迎follow IG: potatopigtongue。572Please respect copyright.PENANApl4usAAJxZ
572Please respect copyright.PENANAtLVm98Rcg1
https://www.instagram.com/potatopigtongue/572Please respect copyright.PENANAZwJV6rHtqr
572Please respect copyright.PENANA5OFDTyqgWb
Ref1:https://www.nature.com/articles/s41588-020-00727-5
00
ns216.73.216.6da2