真菌感染(Fungi Infection)約引致全球每年約二百萬人的死亡,而現今對抗真菌(Fungi)的藥物類別主要共分為三大類別。435Please respect copyright.PENANAyAMqnfRrap435Please respect copyright.PENANAIjIHuDCIJk
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(圖2)三大類別的藥物機制雖有不同,但最終目的均是透過破壞真菌的外層結構來抑制其生長。435Please respect copyright.PENANAaMls5Q6Q44435Please respect copyright.PENANAT7EcQgx6WI
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1.Azole435Please respect copyright.PENANAyt0ib9lH1h
抑制構成細胞膜的Ergosterol產生435Please respect copyright.PENANAhoDRAT5VBy
2. Polyene435Please respect copyright.PENANA5K2DY1qQR7
消耗細胞膜的Ergosterol435Please respect copyright.PENANAVnyon7ac5k
3. Echinocandins435Please respect copyright.PENANAoAFIOfxoMM
抑制構成細胞外層的糖分組織產生435Please respect copyright.PENANAjcrZOENqSC
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(圖3)然而,現今出現了某一類別的Candida auris,上述三款的藥物均對它無法作出顯著功效。435Please respect copyright.PENANAvboyQoRYsY435Please respect copyright.PENANAGDMVbmugl3
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它能夠透過血液循環系統走進全身各部位,引發感染。435Please respect copyright.PENANAmMFm3OJGBJ
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就在2018年,英國急症室病人出現大規模Candida auris的感染,後來證實為共用探熱針所致(Ref1)。435Please respect copyright.PENANANgG7WbpRaA
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(圖4)有科學家近日發表文章(Ref2),在居住在深海生物的微生物中分離出命名為Turbinmicin的天然物質。435Please respect copyright.PENANAqrvwSRgbpw435Please respect copyright.PENANApLR1Y0co1r
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Turbinmicin能有效抑制不同真菌品種,包括Candida auris。435Please respect copyright.PENANA7rW62gmRdt
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它的機制乃為影響內部的蛋白質運輸,與現今三類抑制外圍結構的機制不同,可能因而能夠擊殺得到抵擋現今三大類藥物的Candida auris。435Please respect copyright.PENANAVhRVY0IN8x
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它並不會對人體的紅血球造成傷害,高劑量的使用亦沒有對老鼠做成影響,同時亦能治理Candida auris在老鼠體內所引發的感染。435Please respect copyright.PENANAqw3XHXQ2WT
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但會否引起副作用或其他問題,還需要進一步的研究確實後,才能開啟人類試驗。435Please respect copyright.PENANAnzwDdPXnAQ
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深海一直是未被深入發掘的領域,這一次找到對抗耐藥真菌曙光,日後可能會繼續有意想不到的驚喜。435Please respect copyright.PENANA7ypHzBzC5z
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Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc435Please respect copyright.PENANAVwBwCgxts7
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Ref1:https://www.nejm.org/doi/full/10.1056/NEJMc1900112435Please respect copyright.PENANAiqQbNt4iFf
Ref2:https://science.sciencemag.org/content/370/6519/974435Please respect copyright.PENANAchA9YlUpG9