往不同動物例如老鼠及線蟲注射治療糖尿病的藥物(Metformin)後,壽命均會有顯著的增長。652Please respect copyright.PENANA6Q06JZxflD652Please respect copyright.PENANAnaLk0jN45i
652Please respect copyright.PENANATmKZquVYBM
有研究利用現成資料庫作對比,發現服用Metformin的糖尿病人歲數比沒有服用Metformin的健康人士為長(Ref1),亦有臨床研究嘗試為14名70歲的健康老人家注射為期6星期的Metformin,藉觀察體內的轉變以作抗衰老藥的研究基礎(Ref2)。652Please respect copyright.PENANAYve6Z1Zw73
652Please respect copyright.PENANAYEuXQ7cbBp
(圖2)從圖中可見,往年輕線蟲注射Metformin的話,牠們的生存日子便會增長。652Please respect copyright.PENANAA9gALnDfVG652Please respect copyright.PENANAsklc1x1se7
652Please respect copyright.PENANATwDxnPeEyg
(圖3)但是,與年輕線蟲相反,往年老的線蟲注射Metformin的話,牠們的生存日子不但沒有增加,反而會減少。652Please respect copyright.PENANAQlDRSY1nyj652Please respect copyright.PENANAfqumZb6GFU
652Please respect copyright.PENANASMqWJDTG15
652Please respect copyright.PENANA1UjihCYcgd
(圖4)經過一系列的實驗,科學家認為Metformin能夠驅使年輕線蟲延壽的其中一個原因,是與粒線體的整體功用有關(Ref3)。652Please respect copyright.PENANAI2IeDfQo7p652Please respect copyright.PENANALzEgSwloNd
652Please respect copyright.PENANAQiw4vEsLot
其中,Metformin為年輕線蟲的新陳代謝作出轉變,包括增加碳水化合物的分解,減低脂肪的含量等,但年老的線蟲卻沒能夠觸發同樣的效果,反而更會因新陳代謝機制的不良負荷而增加死亡率。652Please respect copyright.PENANAV3vYUcX1BZ
652Please respect copyright.PENANAqvATdstV12
文中的科學家亦就此作出質疑,既然Metformin只能使年輕線蟲而非年老線蟲延壽,那又究竟是否值得「魯莽」地對健康老人家進行Metformin的延壽研究。652Please respect copyright.PENANAWSi7BqeYjZ
652Please respect copyright.PENANAfsDwQAhsoE
652Please respect copyright.PENANA6yta3BuAn1
如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。652Please respect copyright.PENANAVN3qRdMhut
652Please respect copyright.PENANAPklqMzDXSH
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc652Please respect copyright.PENANA3ApufMttaU
652Please respect copyright.PENANAA8qGSCvflJ
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。652Please respect copyright.PENANAM3ICvrsyxW
652Please respect copyright.PENANARj5X41Zzo8
Link:652Please respect copyright.PENANAFBhKpSzAy2
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio652Please respect copyright.PENANAmnSAaKB59W
652Please respect copyright.PENANAoqo466qNjq
有興趣接收科學資訊的話,歡迎follow IG: potatopigtongue。652Please respect copyright.PENANASNcNVBjU7B
652Please respect copyright.PENANATIK3vE9hKP
https://www.instagram.com/potatopigtongue/652Please respect copyright.PENANAJNS5ux5Lxa
652Please respect copyright.PENANAgx0nE8b2Vy
652Please respect copyright.PENANA4Rs5x2Uk2e
652Please respect copyright.PENANAHqWu3sxL2D
652Please respect copyright.PENANAm9zFUCaiCn
Ref1:https://pubmed.ncbi.nlm.nih.gov/25041462/652Please respect copyright.PENANADvy5jVhUgA
Ref2:https://pubmed.ncbi.nlm.nih.gov/29383869/652Please respect copyright.PENANAWpHhC2cwFD
Ref3:https://www.nature.com/articles/s42255-020-00307-1652Please respect copyright.PENANAsuLs3BdOnh