肌肉大概佔據身體重量的40%。508Please respect copyright.PENANAXVJDwpHQw8508Please respect copyright.PENANA9NA4Tmwux4
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踏入50歲後,平均每10年就會有15-30%的肌肉流失。508Please respect copyright.PENANA2wU1CHGS9v
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(圖2)研究(Ref1)顯示老人家的肌肉裡頭,一隻名為15-PGDH的蛋白酶數量普遍地比年輕人為高。508Please respect copyright.PENANATmyjpOYICY508Please respect copyright.PENANAJeNSicGVFb
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而15-PGDH其中一道作用就是負責將激素PGE2及PGD2分解成為其他物質。508Please respect copyright.PENANA6ORrJX5az2
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(圖3)而人類老化所出現的現象,老鼠亦能同樣發現得到。508Please respect copyright.PENANAeldId1Ct03
除肌肉外,年長老鼠的心、肝、脾、大腸及皮膚亦出現15-PGDH蛋白酶上升的現象。508Please respect copyright.PENANAa13vt3kJjP508Please respect copyright.PENANAgYepHRbcsn
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當利用藥物或基因工程手段降低年老老鼠的15-PGDH數量的話,肌肉重量亦會有所提升。508Please respect copyright.PENANAbgNdTd6SKg
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相反,若強行在年輕老鼠肌肉裡頭強行表達15-PGDH的話,肌肉重量亦會有所下降。508Please respect copyright.PENANAiluKAE5AhJ
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這道研究展示出,只需對一隻蛋白酶作出針對性的抑制,便能夠達到控制肌肉重量及結構的奇效。508Please respect copyright.PENANAHaGVr3J6Tj
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現時已有藥物可抑制15-PGDH,但對於人類肌肉影響的臨床研究則欠奉。508Please respect copyright.PENANA5WfMnBOKdX
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只不過的是,現今均普遍認為增加體內細胞NAD數量的話,便可舒緩甚至是扭轉細胞的老化現象。然而,15-PGDH卻需要NAD才能正常運作,這一方面所出現的矛盾則未能解釋得到。508Please respect copyright.PENANAe22Tmob5cv
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基於WhatsApp/Facebook等問題,IG將不會再作更新,只會寄居本土LIHKG及Penana。508Please respect copyright.PENANAoxPzf1mZJ7
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Ref1:https://science.sciencemag.org/content/371/6528/eabc8059508Please respect copyright.PENANADMTZf4g3oh