肌肉大概佔據身體重量的40%。537Please respect copyright.PENANAKabmk1UXNx537Please respect copyright.PENANA4gYJto9G7M
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踏入50歲後,平均每10年就會有15-30%的肌肉流失。537Please respect copyright.PENANA365wNEVcDo
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(圖2)研究(Ref1)顯示老人家的肌肉裡頭,一隻名為15-PGDH的蛋白酶數量普遍地比年輕人為高。537Please respect copyright.PENANAVQtuL975p8537Please respect copyright.PENANAAaKp32Um1u
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而15-PGDH其中一道作用就是負責將激素PGE2及PGD2分解成為其他物質。537Please respect copyright.PENANAUKROnMfPzh
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(圖3)而人類老化所出現的現象,老鼠亦能同樣發現得到。537Please respect copyright.PENANAnKl7bV0Coc
除肌肉外,年長老鼠的心、肝、脾、大腸及皮膚亦出現15-PGDH蛋白酶上升的現象。537Please respect copyright.PENANA1cbPkWsKz0537Please respect copyright.PENANA83mPG5vQ3L
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當利用藥物或基因工程手段降低年老老鼠的15-PGDH數量的話,肌肉重量亦會有所提升。537Please respect copyright.PENANAV30d2Ya8s3
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相反,若強行在年輕老鼠肌肉裡頭強行表達15-PGDH的話,肌肉重量亦會有所下降。537Please respect copyright.PENANAzgz3hOE7NH
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這道研究展示出,只需對一隻蛋白酶作出針對性的抑制,便能夠達到控制肌肉重量及結構的奇效。537Please respect copyright.PENANAqoFUW3BFJU
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現時已有藥物可抑制15-PGDH,但對於人類肌肉影響的臨床研究則欠奉。537Please respect copyright.PENANAPO08i4EXHS
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只不過的是,現今均普遍認為增加體內細胞NAD數量的話,便可舒緩甚至是扭轉細胞的老化現象。然而,15-PGDH卻需要NAD才能正常運作,這一方面所出現的矛盾則未能解釋得到。537Please respect copyright.PENANAb37NiXqCM4
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同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。537Please respect copyright.PENANAWhaXuM6Qnz
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基於WhatsApp/Facebook等問題,IG將不會再作更新,只會寄居本土LIHKG及Penana。537Please respect copyright.PENANA5mceEyPMJ8
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Ref1:https://science.sciencemag.org/content/371/6528/eabc8059537Please respect copyright.PENANA0B22uCBNFr