肌肉大概佔據身體重量的40%。510Please respect copyright.PENANAoUZSaLQK6E510Please respect copyright.PENANASkgcP2dbRG
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踏入50歲後,平均每10年就會有15-30%的肌肉流失。510Please respect copyright.PENANA062Xuvbo72
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(圖2)研究(Ref1)顯示老人家的肌肉裡頭,一隻名為15-PGDH的蛋白酶數量普遍地比年輕人為高。510Please respect copyright.PENANA7psKeyGFp5510Please respect copyright.PENANAGWvImXPjxy
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而15-PGDH其中一道作用就是負責將激素PGE2及PGD2分解成為其他物質。510Please respect copyright.PENANA7G9c8e4ueM
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(圖3)而人類老化所出現的現象,老鼠亦能同樣發現得到。510Please respect copyright.PENANAKTzeUGpSMU
除肌肉外,年長老鼠的心、肝、脾、大腸及皮膚亦出現15-PGDH蛋白酶上升的現象。510Please respect copyright.PENANAbk5EBp98yX510Please respect copyright.PENANAZ91hzppvnO
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當利用藥物或基因工程手段降低年老老鼠的15-PGDH數量的話,肌肉重量亦會有所提升。510Please respect copyright.PENANAVD2nOiKRmt
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相反,若強行在年輕老鼠肌肉裡頭強行表達15-PGDH的話,肌肉重量亦會有所下降。510Please respect copyright.PENANAlk6eyduEgb
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這道研究展示出,只需對一隻蛋白酶作出針對性的抑制,便能夠達到控制肌肉重量及結構的奇效。510Please respect copyright.PENANAJs4tClAeOQ
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現時已有藥物可抑制15-PGDH,但對於人類肌肉影響的臨床研究則欠奉。510Please respect copyright.PENANAg4u1vEshbE
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只不過的是,現今均普遍認為增加體內細胞NAD數量的話,便可舒緩甚至是扭轉細胞的老化現象。然而,15-PGDH卻需要NAD才能正常運作,這一方面所出現的矛盾則未能解釋得到。510Please respect copyright.PENANANcvJLL4FPd
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Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc510Please respect copyright.PENANAxphRXODDVi
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同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。510Please respect copyright.PENANA38eMaTc1KL
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Link:510Please respect copyright.PENANAY3uxkrCmBq
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基於WhatsApp/Facebook等問題,IG將不會再作更新,只會寄居本土LIHKG及Penana。510Please respect copyright.PENANAVMKT1q16ow
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Ref1:https://science.sciencemag.org/content/371/6528/eabc8059510Please respect copyright.PENANAVZr7ecROaC