不少的癌症病人均會出現體重及BMI急速下降的情況,肌肉會出現萎縮,脂肪組織亦有機會有所消耗,這現象稱之為Cancer-associated cachexia(CAC)。478Please respect copyright.PENANA6s31HoDLPV478Please respect copyright.PENANAieUFj4cq51
478Please respect copyright.PENANAMSYtKSODRT
與厭食症不同的是,體重的流失並沒能依靠增加進食來進行完全填補。478Please respect copyright.PENANAQC66L4WYFY
478Please respect copyright.PENANABdFue6gfXl
(圖2)CAC的形成,是腫瘤與身體多種器官互動後所得出的結果,箇中涉及新陳代謝及荷爾蒙的轉變。478Please respect copyright.PENANATkCk14f0Di478Please respect copyright.PENANAoycYY3fvNW
478Please respect copyright.PENANAEGkJ0tllCb
478Please respect copyright.PENANAPJHagZPVQm
(圖3)從圖中所見,老鼠出現腫瘤約21日後,腿部肌肉出現萎縮,與人類的CAC現象吻合。478Please respect copyright.PENANAEsbAqN8WDm478Please respect copyright.PENANAIAmTbHocmu
478Please respect copyright.PENANAazlGCTdbnI
PTHrP是一種某類型的腫瘤釋放到血管的蛋白質,而往老鼠注射PTHrP蛋白質抗體的話,肌肉的萎縮程度亦有所緩和。478Please respect copyright.PENANAZi0VHM9fqV
478Please respect copyright.PENANAJ1JcvbbzHy
只可是,往健康老鼠注射PTHrP蛋白質的話,肌肉並不會貿然萎縮,而往出現腫瘤的老鼠注射PTHrP蛋白質的話,肌肉萎縮的程度反會更加劇烈。478Please respect copyright.PENANAmu2HNSJKUl
478Please respect copyright.PENANAW3wxPMxqKb
這亦證明,PTHrP蛋白質只是導致癌症時候肌肉萎縮的其中一道組件,還需要癌細胞另外的付出才可達成。478Please respect copyright.PENANACu3l8HiicS
478Please respect copyright.PENANAJShBMOB1sV
478Please respect copyright.PENANA5MVhQT11NX
癌症所帶來的CAC現象,會導致藥物對其他正常器官出現更強烈的副作用及毒性。這變相需要降低用藥的劑量作出配合,因而減低了滅癌的效率。478Please respect copyright.PENANA0Q93cEQq24
478Please respect copyright.PENANAonJ1o5Z5BF
因此,現今科學家亦在努力嘗試找出CAC的整套機制,務求找出有效的醫學方法制止CAC的產生。478Please respect copyright.PENANAuXEJOdxnFW
478Please respect copyright.PENANAxYD3rkVKq0
如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。478Please respect copyright.PENANAs3IulsCWfx
478Please respect copyright.PENANA05Tu06BJGV
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc478Please respect copyright.PENANA99W14C1k2V
478Please respect copyright.PENANA8Cz0yhQyI3
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。478Please respect copyright.PENANA4A3e7wLB5D
478Please respect copyright.PENANAwdXK0asVIC
Link:478Please respect copyright.PENANAlyPkyWTusH
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio478Please respect copyright.PENANAPLZWOqyR4K
478Please respect copyright.PENANAFb9rsYwIXs
478Please respect copyright.PENANA7FO62Z5gIr
基於WhatsApp/Facebook等問題,IG將不會再作更新,只會寄居本土LIHKG及Penana。478Please respect copyright.PENANAN6eVdB6Xal
478Please respect copyright.PENANAFF2a8NFIMJ
Ref1:https://www.nature.com/articles/nature13528478Please respect copyright.PENANAM8ECSZkYXS