上集略述了心臟肥大與心臟衰竭的關連,今集將會講述一道暫緩心臟由肥大演變成衰竭的研究。577Please respect copyright.PENANAtWhYk4HSpq577Please respect copyright.PENANAXpLVtT9kl4
577Please respect copyright.PENANADKuLfbZoOi
上集:https://lih.kg/gOrCdS577Please respect copyright.PENANACN8kYiWfYT
577Please respect copyright.PENANAc48VkQEHhm
(圖2)研究發現,當利用縫線手法引致心臟處於肥大狀態的時候,一隻名為GRK5的蛋白質會從心肌細胞的內部轉移到細胞核裡頭。577Please respect copyright.PENANA55f3QkJ2lF577Please respect copyright.PENANAVHbRmYXSsZ
577Please respect copyright.PENANAFpnxUNBK9H
577Please respect copyright.PENANA6zasvWVmMj
(圖3)當GRK5進入細胞核後,它便會依靠圖中其紅色的部份與其他蛋白質(橙色)互動,因而改變其自身的形狀,發揮一系列的功效引致心臟肥大。577Please respect copyright.PENANAZTGeg7OKqE577Please respect copyright.PENANAbZzht4slaO
577Please respect copyright.PENANAK32RpzSYl5
見狀,科學家便特意單獨注入其紅色部份到細胞核,目的就是想透過紅色部份的霸佔,阻截完整的GRK5蛋白質與其他蛋白質(橙色)互動,使其功效喪失。577Please respect copyright.PENANAa88GPoNVaX
577Please respect copyright.PENANAfkXCHhRN3z
形象化來說,就是某勢力派人霸佔旁聽座位,讓其他人士無法入座。577Please respect copyright.PENANA9EcSVcXPP9
577Please respect copyright.PENANANVhtXhfZKQ
577Please respect copyright.PENANAU9nvK3YyTd
(圖4)縫線後所引起的心臟肥大,並沒有出現在注入紅色部份蛋白質的老鼠心臟裡頭。577Please respect copyright.PENANAUHIoEPdhCv577Please respect copyright.PENANAq3r29mJDLd
577Please respect copyright.PENANAMvXXUEcFK7
最為重要的是,心臟肥大所引起的心肌纖維化(藍色箭嘴),並沒有能夠在注入紅色部份蛋白質的老鼠心臟裡頭找得到。577Please respect copyright.PENANAsNZR7FfsXD
577Please respect copyright.PENANARS6Bm45p71
577Please respect copyright.PENANA4cDczpL6Uj
換句話說,這GRK5的紅色部份,非常之有潛質可以發展成為抵抗血壓過高引致的心臟肥大藥物。577Please respect copyright.PENANAYhEekvwhHM
577Please respect copyright.PENANAPmeLl4aF00
577Please respect copyright.PENANAWIew2RZqa9
577Please respect copyright.PENANAVFvHlCcmdV
577Please respect copyright.PENANAPvCcNDuIDu
577Please respect copyright.PENANAMPtNnlHQPn
如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。577Please respect copyright.PENANAdeI6kp2XM9
577Please respect copyright.PENANAt1Lcuaxe7Q
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc577Please respect copyright.PENANAHzmn8wkExH
577Please respect copyright.PENANAl1Lyfpxrit
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。577Please respect copyright.PENANAZwGUmaCv1i
577Please respect copyright.PENANAYpf2puHNYq
Link:577Please respect copyright.PENANA6uhSAZqhIv
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio577Please respect copyright.PENANAVfRLoKvATw
577Please respect copyright.PENANAYBVN9hwUYL
577Please respect copyright.PENANAFwkfUqUcoq
除非Facebook及IG重開侵侵的account,否則我的IG將不會再作更新,只會寄居本土LIHKG及Penana。577Please respect copyright.PENANA2Chf5I7dup
577Please respect copyright.PENANA9tgK6rKA43
Ref1:https://stke.sciencemag.org/content/14/676/eabb5968577Please respect copyright.PENANA5MGatcaDb9