癌細胞從原位轉移到另一器官,亦即是Metastasis,是癌病患者主要的死因。301Please respect copyright.PENANALfZKJxS23a301Please respect copyright.PENANARhMg9jJzyB
301Please respect copyright.PENANA25MhyfnUPP
「有趣的是」,癌細胞雖近乎不會轉移到肌肉位置裡頭,但卻能從遠處釋放物質,經由血管抵達肌肉位置,催使肌肉萎縮,亦即是癌症惡病質(cancer cachexia)。301Please respect copyright.PENANAWiy11t6V3K
301Please respect copyright.PENANA3xGEv3bhae
(圖2)肌肉萎縮不但之令病人變得虛弱,難以接近正常劑量的化療,更為致命的是,當心臟肌肉及橫隔膜肌肉亦遭受到萎縮的時候,病人便會因呼吸困難等問題而逝死。301Please respect copyright.PENANALxK32TPL5f301Please respect copyright.PENANAf3kmSADi5h
301Please respect copyright.PENANARw8fwhqd8I
早在1858年已有科學家指出cancer cachexia的存在,但至今2021年仍是沒有FDA認可藥物治療cancer cachexia。301Please respect copyright.PENANAJxP7EUmSmq
301Please respect copyright.PENANAe9KZFbXvLT
(圖3)現時有不少臨床研究希望可以制衡cancer cachexia,普遍均是從營養方面入手。301Please respect copyright.PENANAzQanE31j1T301Please respect copyright.PENANAirNaJ1rnQT
301Please respect copyright.PENANAcl5D3ZKg8J
但結果大多數是只能夠增加病人的脂肪組織,而沒能夠填補已萎縮的肌肉。301Please respect copyright.PENANAN1iKY7hJ8P
301Please respect copyright.PENANAckZJ4X5UXo
有一點值得注意的是,肌肉細胞並非是死去,純粹是其分解蛋白質的進程比生產蛋白質的進程來得更快,因而形成萎縮。301Please respect copyright.PENANAkxNerjxA1J
301Please respect copyright.PENANAFwYxTGTHGT
301Please respect copyright.PENANApHDO65Thfs
(圖4)從研究Cancer cachexia的老鼠模型中可以看到,患癌的老鼠不但更為細小,其手腕的握力度亦有所下降。301Please respect copyright.PENANAPwntIyCh6q301Please respect copyright.PENANA4ecZsEZviW
301Please respect copyright.PENANAlysd5eu4fu
觀察肌肉細胞橫切面的面積時,亦可以看到肌肉細胞的面積明顯有所縮細。301Please respect copyright.PENANARifeOGTycU
301Please respect copyright.PENANACFE2IWi5cW
301Please respect copyright.PENANAYWfHOvYCfh
301Please respect copyright.PENANAK79iAU70gF
下集將會講解Cancer cachexia的老鼠模型所得出的其中一道結果。301Please respect copyright.PENANALnuxLMv3NJ
301Please respect copyright.PENANAIpvYkWvRPv
如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。301Please respect copyright.PENANAjIV84NNGiI
301Please respect copyright.PENANA0OswMaHifj
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc301Please respect copyright.PENANAyAP7StX4Uq
301Please respect copyright.PENANAqiCTT41pYj
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。301Please respect copyright.PENANAqBZNdNjjFP
301Please respect copyright.PENANAfQN5e0eKJR
Link:301Please respect copyright.PENANAqjeViftY7G
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio301Please respect copyright.PENANAYVOFb2R6hI
301Please respect copyright.PENANA7ksLKitzBv
301Please respect copyright.PENANA6nq1zYMZW3
除非Facebook及IG重開侵侵的account,否則我的IG將不會再作更新,只會寄居本土LIHKG及Penana。301Please respect copyright.PENANAzAMwrzqBWb
301Please respect copyright.PENANAvZ1J81nXFF
Ref1:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015555/301Please respect copyright.PENANA7kAHhheMkS