癌細胞從原位轉移到另一器官,亦即是Metastasis,是癌病患者主要的死因。503Please respect copyright.PENANATlx8SD0acR503Please respect copyright.PENANAkSRrFmbjbz
503Please respect copyright.PENANAjlIl561ciB
「有趣的是」,癌細胞雖近乎不會轉移到肌肉位置裡頭,但卻能從遠處釋放物質,經由血管抵達肌肉位置,催使肌肉萎縮,亦即是癌症惡病質(cancer cachexia)。503Please respect copyright.PENANAWeKWVUyWfn
503Please respect copyright.PENANAmN5uZhUk8H
(圖2)肌肉萎縮不但之令病人變得虛弱,難以接近正常劑量的化療,更為致命的是,當心臟肌肉及橫隔膜肌肉亦遭受到萎縮的時候,病人便會因呼吸困難等問題而逝死。503Please respect copyright.PENANAQrU2NqeTN8503Please respect copyright.PENANAlPwe4FtTYQ
503Please respect copyright.PENANAcGaE4XLWZ1
早在1858年已有科學家指出cancer cachexia的存在,但至今2021年仍是沒有FDA認可藥物治療cancer cachexia。503Please respect copyright.PENANANAom8ZTNvi
503Please respect copyright.PENANAT349oOLnV0
(圖3)現時有不少臨床研究希望可以制衡cancer cachexia,普遍均是從營養方面入手。503Please respect copyright.PENANAZg3c4cCUWt503Please respect copyright.PENANAv1hYf6iMRj
503Please respect copyright.PENANAxKfrnqCWf4
但結果大多數是只能夠增加病人的脂肪組織,而沒能夠填補已萎縮的肌肉。503Please respect copyright.PENANAQH7GvQ3v5h
503Please respect copyright.PENANA4h634np7LW
有一點值得注意的是,肌肉細胞並非是死去,純粹是其分解蛋白質的進程比生產蛋白質的進程來得更快,因而形成萎縮。503Please respect copyright.PENANAaPpDlFYgdo
503Please respect copyright.PENANAs43M7qES9Z
503Please respect copyright.PENANAeBRbXNpSVu
(圖4)從研究Cancer cachexia的老鼠模型中可以看到,患癌的老鼠不但更為細小,其手腕的握力度亦有所下降。503Please respect copyright.PENANAf6bSrMRspt503Please respect copyright.PENANAtMOtvQOqyx
503Please respect copyright.PENANAODLycdDVlC
觀察肌肉細胞橫切面的面積時,亦可以看到肌肉細胞的面積明顯有所縮細。503Please respect copyright.PENANAa1aZDMtEkW
503Please respect copyright.PENANA2W1fDTKqXG
503Please respect copyright.PENANAmnPtLvPczR
503Please respect copyright.PENANAjEzlWGlGKV
下集將會講解Cancer cachexia的老鼠模型所得出的其中一道結果。503Please respect copyright.PENANAdiXhmqAp7M
503Please respect copyright.PENANAUIK431FtKI
如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。503Please respect copyright.PENANAhSGDdcYmQL
503Please respect copyright.PENANA6OtYpdxEtH
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc503Please respect copyright.PENANAM29N6L7qYg
503Please respect copyright.PENANAulePqRpykP
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。503Please respect copyright.PENANAYgXkDanpfe
503Please respect copyright.PENANAvyAmMBM9dy
Link:503Please respect copyright.PENANAFTJsnSgBWv
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio503Please respect copyright.PENANA2AHnhQb6KK
503Please respect copyright.PENANAoJ32vnSrAG
503Please respect copyright.PENANAe0mTy2I6es
除非Facebook及IG重開侵侵的account,否則我的IG將不會再作更新,只會寄居本土LIHKG及Penana。503Please respect copyright.PENANAKxqpbCkwv7
503Please respect copyright.PENANApABnbW0XMB
Ref1:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015555/503Please respect copyright.PENANA662r7Hj0Tr