藥物的效用有時候因人而異,其中一道原因,可以歸究於每個人體內的腸道細菌品種有所不同所致。479Please respect copyright.PENANAPyq4uXxakc479Please respect copyright.PENANAkJgYyuiTY2
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(圖2)口服藥物要抵達血管循環系統的話,無可避免將會途經我們的腸道。479Please respect copyright.PENANAZM0UM6C42a
而我們腸道的細菌有能力改造或代謝藥物,因而改變藥物結構及其效用。479Please respect copyright.PENANAPgHxI0dEue479Please respect copyright.PENANADAd4xgxXGX
479Please respect copyright.PENANAr00KSPmzJP
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479Please respect copyright.PENANAQEKVDYt8dm
(圖3)有科學家找來人體最為常見的76種腸道細菌品種,與271款不同界別常用的藥物共同放在一起12小時。479Please respect copyright.PENANAS9aMIaUIJN479Please respect copyright.PENANAdYBDZBYWEP
479Please respect copyright.PENANA6M7iTIfm6k
最終發現,271款藥物中,有多達176款藥物的濃度在被至少一種腸道細菌影響下,濃度減少了20%;479Please respect copyright.PENANA2ozCBy2tDP
而這些腸道細菌品種每款可以代謝11-95款藥物不等。479Please respect copyright.PENANAHm0cZOeLHj
479Please respect copyright.PENANAqxSMnLJ3F1
用上老鼠作動物模型,科學家更能找出所屬細菌哪一條基因負責消化/代謝藥物,引證腸道細菌影響藥物吸收的理念。479Please respect copyright.PENANAmvcBpxoqDL
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倘若你腸道恰巧住有細菌A,而細菌A又有能力吸收你所口服的藥物,那麼藥效便有可能會大大減低。479Please respect copyright.PENANAqZU7CBLKwl
479Please respect copyright.PENANApmYzN0c2yI
血液注射而非口服的藥物將有機會不受此限,因為藥物並不需一定要經過腸道裡頭。479Please respect copyright.PENANA9IX6GshoSX
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如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。479Please respect copyright.PENANASmFtByZxUR
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Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc479Please respect copyright.PENANAw4Kyywev1d
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同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。479Please respect copyright.PENANAF7LUP7wxIF
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Link:479Please respect copyright.PENANA1iVUxmv0YH
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio479Please respect copyright.PENANAys5K6xS0Y7
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除非Facebook及IG重開侵侵的account,否則我的IG將不會再作更新,只會寄居本土LIHKG及Penana。479Please respect copyright.PENANAJouvhhrUmN
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Ref1:https://www.nature.com/articles/s41586-019-1291-3479Please respect copyright.PENANAhCz7mqPOCz