當細胞裡頭出現多餘或者已受損毀的物質,又或者是細胞面臨營養不足的情況,細胞便會啟動名為自噬(Autophagy)的機制,依靠溶酶體(lysosome)將物質消化成為蛋白質/糖份/脂肪,供自己能量或物質所需。541Please respect copyright.PENANA949DhIU1aJ541Please respect copyright.PENANAtHHeTrs5rU
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早前亦有提及Cancer-associated fibroblasts如何利用自噬(Autophagy)幫助癌細胞生長。541Please respect copyright.PENANAsHu5maVO5L
三十秒科學–癌細胞也會自肥?541Please respect copyright.PENANASwYESeFILZ
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(圖2)自噬(Autophagy)機制能夠讓細胞在營養不足的情況摧毀多餘的物質,使自己得以在困局下苟延殘喘。541Please respect copyright.PENANA5tkI6iTrnL541Please respect copyright.PENANA9OWNhDxGKJ
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情形就如人們債務纏身而又沒有收入抵債的時候,只好變賣自己所持有的資產,化成現金抵償。541Please respect copyright.PENANAh61BcNzmiQ
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由此可以想像,這是一道治標不治標的方法。541Please respect copyright.PENANA3gNJaXdn6C
當長期沒有營養流入細胞,而細胞再也沒有多餘物質進行自噬的時候,細胞便會啟動自行滅亡的機制。541Please respect copyright.PENANAxFBV86SmFP
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(圖3)如果催谷癌細胞不斷進行自噬作用的話,促使它們啟動自行滅亡的機制,那豈不是殺滅它們的一道妙計?541Please respect copyright.PENANAln13NbkO2X541Please respect copyright.PENANAi5TNJNHGk7
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很遺憾地,各款癌細胞對於自噬作用的依賴及抗性均有所不同,難以就此單一針對自噬作用來消滅癌細胞。541Please respect copyright.PENANAxsskFx1vPb
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暫時較為統一的發現是,大多數的胰臟癌細胞均非常依賴自噬作用來維持自己的生長速度。541Please respect copyright.PENANACSfdd3IyNE
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在實驗室細胞模型及老鼠實驗中,若果對胰臟癌細胞使用抑制自噬作用的藥物,不但改變它們的新陳代謝,且可減慢癌細胞的生長速度,非常之有潛質成為對抗胰臟癌的其中一手段。541Please respect copyright.PENANAQEZOgqSLc0
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如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。541Please respect copyright.PENANArZHstOLjMF
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Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc541Please respect copyright.PENANAZ2iw04TbeQ
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同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。541Please respect copyright.PENANA9iMY0FJsIH
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Link:541Please respect copyright.PENANAM6UrQ6MUKD
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio541Please respect copyright.PENANA5BVfBIdkAf
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除非Facebook及IG重開侵侵的account,否則我的IG將不會再作更新,只會寄居本土LIHKG及Penana。541Please respect copyright.PENANAlnhGwPCYtp
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Ref1:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3070934/541Please respect copyright.PENANAyc7wHqUJEY
Ref2:https://cancerres.aacrjournals.org/content/66/19/9349.long
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