當細胞裡頭出現多餘或者已受損毀的物質,又或者是細胞面臨營養不足的情況,細胞便會啟動名為自噬(Autophagy)的機制,依靠溶酶體(lysosome)將物質消化成為蛋白質/糖份/脂肪,供自己能量或物質所需。363Please respect copyright.PENANAUskmAVgQlT363Please respect copyright.PENANAaDy2YPk5iO
363Please respect copyright.PENANAXRDoECqBIN
早前亦有提及Cancer-associated fibroblasts如何利用自噬(Autophagy)幫助癌細胞生長。363Please respect copyright.PENANADeTyzk7lc7
三十秒科學–癌細胞也會自肥?363Please respect copyright.PENANAMq4zafrDiI
- 分享自 LIHKG 討論區363Please respect copyright.PENANAkRHlfaK0GZ
https://lih.kg/hgfcNS363Please respect copyright.PENANAGCHXjSNVNV
363Please respect copyright.PENANABMKp4lqlpy
363Please respect copyright.PENANACupGcZzqdC
(圖2)自噬(Autophagy)機制能夠讓細胞在營養不足的情況摧毀多餘的物質,使自己得以在困局下苟延殘喘。363Please respect copyright.PENANA6WHAwMxbTm363Please respect copyright.PENANAaTRNnJeS4Y
363Please respect copyright.PENANAi5rB4PtgNy
情形就如人們債務纏身而又沒有收入抵債的時候,只好變賣自己所持有的資產,化成現金抵償。363Please respect copyright.PENANA186dzlNAGG
363Please respect copyright.PENANAMQ55K0E4Xq
由此可以想像,這是一道治標不治標的方法。363Please respect copyright.PENANAQG0laekTLm
當長期沒有營養流入細胞,而細胞再也沒有多餘物質進行自噬的時候,細胞便會啟動自行滅亡的機制。363Please respect copyright.PENANAzcEsuUGR8D
363Please respect copyright.PENANAILfOIpyMrh
363Please respect copyright.PENANANQO05Su10h
(圖3)如果催谷癌細胞不斷進行自噬作用的話,促使它們啟動自行滅亡的機制,那豈不是殺滅它們的一道妙計?363Please respect copyright.PENANAR7G6FtB9cj363Please respect copyright.PENANAq0WXlwN5tN
363Please respect copyright.PENANAVloNrzaoKo
很遺憾地,各款癌細胞對於自噬作用的依賴及抗性均有所不同,難以就此單一針對自噬作用來消滅癌細胞。363Please respect copyright.PENANAcDTZZxxz3B
363Please respect copyright.PENANANQmxY3TmsZ
暫時較為統一的發現是,大多數的胰臟癌細胞均非常依賴自噬作用來維持自己的生長速度。363Please respect copyright.PENANAEBDvpfAukG
363Please respect copyright.PENANAlVZGGzjqkD
在實驗室細胞模型及老鼠實驗中,若果對胰臟癌細胞使用抑制自噬作用的藥物,不但改變它們的新陳代謝,且可減慢癌細胞的生長速度,非常之有潛質成為對抗胰臟癌的其中一手段。363Please respect copyright.PENANA92VeI8IzY1
363Please respect copyright.PENANA8lx6SP2D7I
363Please respect copyright.PENANAOdEIdCe4VZ
如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。363Please respect copyright.PENANAx7GLMtBPdb
363Please respect copyright.PENANAUUfNeFGj53
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc363Please respect copyright.PENANAUtOTsd7sTX
363Please respect copyright.PENANAZWee2u8T14
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。363Please respect copyright.PENANAy6o1zuOrU9
363Please respect copyright.PENANAd2yBdrBy7g
Link:363Please respect copyright.PENANA6qoMJqF7Xm
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio363Please respect copyright.PENANAxYiN2TiI0K
363Please respect copyright.PENANA2bBDvUUzqa
363Please respect copyright.PENANAE5XjiOxhH6
除非Facebook及IG重開侵侵的account,否則我的IG將不會再作更新,只會寄居本土LIHKG及Penana。363Please respect copyright.PENANA7srx8qfgZB
363Please respect copyright.PENANAXjP1C6pASV
Ref1:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3070934/363Please respect copyright.PENANAXRv1zaZeG8
Ref2:https://cancerres.aacrjournals.org/content/66/19/9349.long
1
0