現今至少有兩間公司的人造抗體(LY/REGN)被緊急認可為武肺的治療方法。537Please respect copyright.PENANAPzUV566vnu537Please respect copyright.PENANAsOSVmnuaDp
537Please respect copyright.PENANAXPoUSdkhpC
但基於這兩種人造抗體需經由血管注射,其間病人需卧床約一小時間,且需求人手密切監察整個過程,實際運行的成本非常高昂,因此未能普及。537Please respect copyright.PENANAD0p5pyPj3X
537Please respect copyright.PENANAMMgaUpgJX1
更甚的是,有數據顯示當人造抗體經血管注射後,能抵達肺部裡頭的數量少至有少(血液抗體含量比肺部抗體含量高出200-500倍有多),且已知當今的武肺病毒變種能有效躲避兩間公司的人造抗體追捕,使至人造抗體的地位日漸式微。537Please respect copyright.PENANAuADRbD0Awk
537Please respect copyright.PENANA2qYTH8NwX7
537Please respect copyright.PENANALiERWwsQu1
(圖2)武肺病毒最主要的作惡地方是肺部,要解決肺部抗體含量過少的問題,其中一道手段就是從鼻腔注射人造抗體,使其能較易直達肺部。537Please respect copyright.PENANAJmW7oQ6054537Please respect copyright.PENANADHlur4Z3CA
537Please respect copyright.PENANAs3JbAuygms
從老鼠模型實驗中,可以見到往鼻腔注射人造抗體後,抗體(紅黃色區域)會聚集在鼻腔(N)及肺部(Lu)裡頭。537Please respect copyright.PENANAbiCCW6wjPt
537Please respect copyright.PENANAIPIZP1RYD5
537Please respect copyright.PENANAbKrgo6Uo4g
(圖3)至於解決武肺變種的問題,其中一手段就是將五個單一抗體連結成一個個體(五合一),利用「龐大」的身驅阻礙病毒進入細胞。537Please respect copyright.PENANAo9YdS0UARc537Please respect copyright.PENANANlwQ38h1cT
537Please respect copyright.PENANAZoZIsZj43F
在老鼠實驗中,鼻噴式的五合一抗體能有效阻隔英國及巴西變種等病毒,且有著預防及治療武肺的功效,同時亦沒有對老鼠的體重和明顯特徵做成任何影響。537Please respect copyright.PENANANfRniJUAzK
537Please respect copyright.PENANAmlJxlbcito
若能順利通過人體臨床實驗,定必為世界的安定起來重要的作用。537Please respect copyright.PENANAZVzL8YvJOf
537Please respect copyright.PENANAtleVSspFGy
537Please respect copyright.PENANAn9nwTFWVFU
537Please respect copyright.PENANAlizMgUJ50E
537Please respect copyright.PENANAfLHrqwsMQe
如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。537Please respect copyright.PENANAvEfaZwLR2R
537Please respect copyright.PENANAZ2VZjV0Z4y
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc537Please respect copyright.PENANAvGF93F6qdd
537Please respect copyright.PENANA3Y5XqbphAX
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。537Please respect copyright.PENANAMLZQlGQQ2k
537Please respect copyright.PENANAsa6xAVF7sm
Link:537Please respect copyright.PENANAXXDFMGdCJe
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio537Please respect copyright.PENANAt8rCupSMvg
537Please respect copyright.PENANAoyJRscaiih
537Please respect copyright.PENANAUfGhr3Alw0
除非Facebook及IG重開侵侵的account,否則我的IG將不會再作更新,只會寄居本土LIHKG及Penana。537Please respect copyright.PENANAtVHirkJefq
537Please respect copyright.PENANAvVgAqG6V0S
Ref1:https://www.nature.com/articles/s41586-021-03673-2_reference.pdf537Please respect copyright.PENANAWhLAYiBAaX